Evidence map›Paper›PMID 29120365›Full record

ArticleInternational journal of molecular sciences2017

Macrophage Migration Inhibitory Factor Predicts Outcome in Complex Aortic Surgery.

Alexander Gombert, Christian Stoppe, Ann Christina Foldenauer, Tobias Schuerholz, Lukas Martin, Johannes Kalder, Gereon Schälte, Gernot Marx, Michael Jacobs, Jochen Grommes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexander GombertEuropean Vascular Center Aachen-Maastricht, Department of Vascular Surgery University Hospital Aachen, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany. agombert@ukaachen.de.
Christian StoppeDepartment of Intensive Care and Intermediate Care, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany. cstoppe@ukaachen.de.
Ann Christina FoldenauerDepartment of Medical Statistics, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany. afoldenauer@ukaachen.de.
Tobias SchuerholzDepartment of Anaesthesia and Intensive Care, University of Rostock, 18059 Rostock, Germany. tobias.Schuerholz@med.uni-rostock.de.
Lukas MartinDepartment of Intensive Care and Intermediate Care, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany. lmartin@ukaachen.de.
Johannes KalderEuropean Vascular Center Aachen-Maastricht, Department of Vascular Surgery University Hospital Aachen, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany. jkalder@ukaachen.de.
Gereon SchälteDepartment of Anesthesiology, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany. gschaelte@ukaachen.de.
Gernot MarxDepartment of Intensive Care and Intermediate Care, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany. gmarx@ukaachen.de.
Michael JacobsEuropean Vascular Center Aachen-Maastricht, Department of Vascular Surgery University Hospital Aachen, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany. mjacobs@ukaachen.de.
Jochen GrommesEuropean Vascular Center Aachen-Maastricht, Department of Vascular Surgery University Hospital Aachen, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany. jgrommes@ukaachen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The perioperative inflammatory response is associated with outcome after complex aortic repair. Macrophage migration inhibitory factor (MIF) shows protective effects in ischemia-reperfusion (IR), but also adverse pro-inflammatory effects in acute inflammation, potentially leading to adverse outcome, which should be investigated in this trial. This prospective study enrolled 52 patients, of whom 29 (55.7%) underwent open repair (OR) and 23 (44.3%) underwent endovascular repair (ER) between 2014 and 2015. MIF serum levels were measured until 72 h post-operatively. We used linear mixed models and ROC analysis to analyze the MIF time-course and its diagnostic ability. Compared to ER, OR induced higher MIF release perioperatively; at 12 h after ICU admission, MIF levels were similar between groups. MIF course was significantly influenced by baseline MIF level (

Indexed as

AgedAortic Aneurysm, ThoracicAortic DissectionAPACHEBiomarkersFemaleHumansInflammationIntramolecular OxidoreductasesLinear ModelsMacrophage Migration-Inhibitory FactorsMaleMiddle AgedPostoperative ComplicationsProspective StudiesROC CurveBiomarkersIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMIF protein, humanintensive care unitmacrophage migration inhibitory factorsurvivalthoracoabdominal aortic aneurysm

Identifiers

PMID29120365
PMCPMC5713343

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.