ArticleeLife2017
Neuropathological and transcriptomic characteristics of the aged brain.
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In one paragraph
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 1 of them a synthesis that pooled it.
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97citing papers in PubMed, 1 pooled it
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Who cites it
97 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review and meta-analysis of bulk RNAseq studies in human Alzheimer's disease brain tissue.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Dysregulation of neuronal androgen receptor signaling by divergent collaborative transcription factors in Alzheimer's disease.iScience · 2026Article
- A pattern to rule them all: tracing a human brain map of molecular aspects shared by Alzheimer's disease and dementia with Lewy bodies.GeroScience · 2026Article
- Sex-specific regulation of angiogenin in Alzheimer's disease.Molecular psychiatry · 2026Article
- USP18/DDX5 axis ameliorates mitochondrial morphofunctional damage via OPA1 to inhibit neuronal apoptosis after traumatic brain injury.Redox biology · 2026Article
- OMICON: a community resource for studying gene coexpression networks in normal and neoplastic human brain samples.bioRxiv : the preprint server for biology · 2026Article
- Protein kinase CK2α' as a dual modulator of neuroimmune signaling and synaptic dysfunction in tauopathy.Translational neurodegeneration · 2026Article
- Nitric oxide drives proteomic diversity through alternative splicing.Molecular cell · 2026Article
- GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Evidence of emerging transcriptome mediators of Alzheimer's disease in canine cognitive dysfunction.Brain pathology (Zurich, Switzerland) · 2026Article
- CK2 inhibition suppresses glial inflammation in models of neuroinflammation and neurodegeneration.Nature communications · 2026Article
- Characterising processing conditions that artifactually bias human brain tissue transcriptomes.Nature communications · 2026Article
- The representation of omitted sounds in the mouse auditory cortex.Nature communications · 2026Article
- Brain multiomic profiling identifies tau-related transcriptomic dysregulation in Alzheimer's disease.Brain communications · 2026Article
- Peripheral blood microarray-based transcriptomic and epigenetic analyses identify immune, inflammation, and metabolic dysregulation in Alzheimer's disease.NPJ dementia · 2026Article
- Genetic Landscape of Opsoclonus-Myoclonus-Ataxia Syndrome in Children.Pediatric neurology · 2025Article
- Identification and validation of PANoptosis-related biomarkers in Alzheimer's disease via single-cell RNA sequencing and machine learning.European journal of medical research · 2025Article
- Protein kinase CK2α' as a dual modulator of immune signaling and synaptic dysfunction in Tauopathy.bioRxiv : the preprint server for biology · 2025Article
- A Machine-Learning Approach Identifies Rejuvenating Interventions in the Human Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Conditional neuronal deletion of microRNA-141/200c cluster, but not microRNA-181a/b-1 cluster, is protective against experimental stroke in male mice.Physiological reports · 2025Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
73 authors.
Jeremy A MillerAllen Institute for Brain Science, Seattle, United States.ORCID 0000-0003-4549-588X
Angela Guillozet-BongaartsAllen Institute for Brain Science, Seattle, United States.
Laura E GibbonsDepartment of Medicine, University of Washington, Seattle, United States.ORCID 0000-0001-5054-2543
Nadia PostupnaDepartment of Pathology, University of Washington, Seattle, United States.
Anne RenzKaiser Permanente Washington Health Research Institute, Seattle, United States.
Allison E BellerDepartment of Pathology, University of Washington, Seattle, United States.
Susan M SunkinAllen Institute for Brain Science, Seattle, United States.
Lydia NgAllen Institute for Brain Science, Seattle, United States.
Shannon E RoseDepartment of Pathology, University of Washington, Seattle, United States.
Kimberly A SmithAllen Institute for Brain Science, Seattle, United States.
Aaron SzaferAllen Institute for Brain Science, Seattle, United States.
Chris BarberAllen Institute for Brain Science, Seattle, United States.
Darren BertagnolliAllen Institute for Brain Science, Seattle, United States.
Kristopher BickleyAllen Institute for Brain Science, Seattle, United States.
Krissy BrounerAllen Institute for Brain Science, Seattle, United States.
Shiella CaldejonAllen Institute for Brain Science, Seattle, United States.
Mike ChapinAllen Institute for Brain Science, Seattle, United States.
Mindy L ChuaDepartment of Pathology, University of Washington, Seattle, United States.
Natalie M ColemanDepartment of Pathology, University of Washington, Seattle, United States.
Eiron CudabackDepartment of Pathology, University of Washington, Seattle, United States.
Christine CuhaciyanAllen Institute for Brain Science, Seattle, United States.
Rachel A DalleyAllen Institute for Brain Science, Seattle, United States.
Nick DeeAllen Institute for Brain Science, Seattle, United States.
Tsega DestaAllen Institute for Brain Science, Seattle, United States.
Tim A DolbeareAllen Institute for Brain Science, Seattle, United States.
Nadezhda I DotsonAllen Institute for Brain Science, Seattle, United States.ORCID 0000-0003-3414-3176
Michael FisherAllen Institute for Brain Science, Seattle, United States.
Nathalie GaudreaultAllen Institute for Brain Science, Seattle, United States.
Garrett GeeAllen Institute for Brain Science, Seattle, United States.
Terri L GilbertAllen Institute for Brain Science, Seattle, United States.
Jeff GoldyAllen Institute for Brain Science, Seattle, United States.
Fiona GriffinAllen Institute for Brain Science, Seattle, United States.
Caroline HabelAllen Institute for Brain Science, Seattle, United States.
Zeb HaradonAllen Institute for Brain Science, Seattle, United States.
Nika HejaziniaAllen Institute for Brain Science, Seattle, United States.
Leanne L HellsternDepartment of Pathology, University of Washington, Seattle, United States.
Steve HorvathDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, United States.
Kim HowardDepartment of Pathology, University of Washington, Seattle, United States.
Robert HowardAllen Institute for Brain Science, Seattle, United States.
Justin JohalAllen Institute for Brain Science, Seattle, United States.
Nikolas L JorstadDepartment of Pathology, University of Washington, Seattle, United States.
Samuel R JosephsenDepartment of Pathology, University of Washington, Seattle, United States.
Chihchau L KuanAllen Institute for Brain Science, Seattle, United States.
Florence LaiAllen Institute for Brain Science, Seattle, United States.
Eric LeeAllen Institute for Brain Science, Seattle, United States.ORCID 0000-0002-7166-0909
Felix LeeAllen Institute for Brain Science, Seattle, United States.
Tracy LemonAllen Institute for Brain Science, Seattle, United States.
Xianwu LiDepartment of Pathology, University of Washington, Seattle, United States.
Desiree A MarshallDepartment of Pathology, University of Washington, Seattle, United States.
Jose MelchorAllen Institute for Brain Science, Seattle, United States.
Shubhabrata MukherjeeDepartment of Medicine, University of Washington, Seattle, United States.
Julie NyhusAllen Institute for Brain Science, Seattle, United States.
Julie PendergraftAllen Institute for Brain Science, Seattle, United States.ORCID 0000-0002-6066-4576
Lydia PotekhinaAllen Institute for Brain Science, Seattle, United States.
Elizabeth Y RhaDepartment of Pathology, University of Washington, Seattle, United States.
Samantha RiceDepartment of Pathology, University of Washington, Seattle, United States.
David RosenAllen Institute for Brain Science, Seattle, United States.
Abharika SapruDepartment of Pathology, University of Washington, Seattle, United States.
Aimee SchantzDepartment of Pathology, University of Washington, Seattle, United States.
Elaine ShenAllen Institute for Brain Science, Seattle, United States.
Emily SherfieldDepartment of Pathology, University of Washington, Seattle, United States.
Shu ShiAllen Institute for Brain Science, Seattle, United States.
Andy J SodtAllen Institute for Brain Science, Seattle, United States.
Nivretta ThatraAllen Institute for Brain Science, Seattle, United States.
Michael TieuAllen Institute for Brain Science, Seattle, United States.
Angela M WilsonDepartment of Pathology, University of Washington, Seattle, United States.
Thomas J MontineDepartment of Pathology, University of Washington, Seattle, United States.
Eric B LarsonKaiser Permanente Washington Health Research Institute, Seattle, United States.
Amy BernardAllen Institute for Brain Science, Seattle, United States.ORCID 0000-0003-2540-1153
Paul K CraneDepartment of Medicine, University of Washington, Seattle, United States.
Richard G EllenbogenDepartment of Neurological Surgery, University of Washington, Seattle, United States.
C Dirk KeeneDepartment of Pathology, University of Washington, Seattle, United States.ORCID 0000-0002-5291-1469
Ed LeinAllen Institute for Brain Science, Seattle, United States.ORCID 0000-0001-9012-6552
Funding
Vascular Structure and Function in Cognitive AgingP01AG003949 · NIA · YESHIVA UNIVERSITY · PI Charles B Hall · 1985 to 2026
$73.9MAlzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4MTHERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2MSUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MFurthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3MTHE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9MResearch Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5MIntegrating the exposome and methylome to inform brain molecular changes in ADRD across established diverse cohorts.U01AG046139 · NIA · UNIVERSITY OF FLORIDA · PI ERTEKIN-TANER, NILUFER, FUNK, CORY · 2013 to 2022
$24.6MRISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4MPathway discovery, validation and compound identification for Alzheimer's disease - SupplementU01AG046152 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2013 to 2017
$13.6MNIA NIH HHS P01 AG003949NIA NIH HHS P01 AG017216NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG019610NIA NIH HHS P50 AG005136NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG025711NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG018023NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG032990NIA NIH HHS R01 AG036836NIA NIH HHS U01 AG006781NIA NIH HHS U01 AG006786NIA NIH HHS U01 AG032984NIA NIH HHS U01 AG046139NIA NIH HHS U01 AG046152NINDS NIH HHS R01 NS080820NINDS NIH HHS U24 NS072026
Abstract
As more people live longer, age-related neurodegenerative diseases are an increasingly important societal health issue. Treatments targeting specific pathologies such as amyloid beta in Alzheimer's disease (AD) have not led to effective treatments, and there is increasing evidence of a disconnect between traditional pathology and cognitive abilities with advancing age, indicative of individual variation in resilience to pathology. Here, we generated a comprehensive neuropathological, molecular, and transcriptomic characterization of hippocampus and two regions cortex in 107 aged donors (median = 90) from the Adult Changes in Thought (ACT) study as a freely-available resource (http://aging.brain-map.org/). We confirm established associations between AD pathology and dementia, albeit with increased, presumably aging-related variability, and identify sets of co-expressed genes correlated with pathological tau and inflammation markers. Finally, we demonstrate a relationship between dementia and RNA quality, and find common gene signatures, highlighting the importance of properly controlling for RNA quality when studying dementia.
Indexed as
Gene Expression ProfilingAgedAged, 80 and overAgingAlzheimer DiseaseCerebral CortexDementiaFemaleHippocampusHumansMaleagingAlzheimer's diseasedementiagene expressionhumanneuroscience
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