ArticleAging cell2018
Running-wheel activity delays mitochondrial respiratory flux decline in aging mouse muscle via a post-transcriptional mechanism.
Article in Aging cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Skeletal muscle proteomics: considerations and opportunities.npj metabolic health and disease · 2025Review
- Environmental Enrichment Improves Motor Function and Muscle Transcriptome of Aged Mice.Advanced biology · 2024Article
- A Kinase Interacting Protein 1 regulates mitochondrial protein levels in energy metabolism and promotes mitochondrial turnover after exercise.Scientific reports · 2023Article
- Phytochemical compound PB125 attenuates skeletal muscle mitochondrial dysfunction and impaired proteostasis in a model of musculoskeletal decline.The Journal of physiology · 2023Article
- Fiber-Type Shifting in Sarcopenia of Old Age: Proteomic Profiling of the Contractile Apparatus of Skeletal Muscles.International journal of molecular sciences · 2023Review
- The impact of metabolism on the adaptation of organisms to environmental change.Frontiers in cell and developmental biology · 2023Article
- Regulation of mitochondrial dynamic equilibrium by physical exercise in sarcopenia: A systematic review.Journal of orthopaedic translation · 2022Review
- Article
- Age-related susceptibility to insulin resistance arises from a combination of CPT1B decline and lipid overload.BMC biology · 2021Article
- Gene expression regulates metabolite homeostasis during the Crabtree effect: Implications for the adaptation and evolution of Metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The effect of voluntary wheel running on the antioxidant status is dependent on sociability conditions.Pharmacology, biochemistry, and behavior · 2020Article
- Review
- Role of GDF15 in active lifestyle induced metabolic adaptations and acute exercise response in mice.Scientific reports · 2019Article
- Transcriptome analysis suggests a compensatory role of the cofactors coenzyme A and NADScientific reports · 2019Article
- Quantifying Dynamic Regulation in Metabolic Pathways with Nonparametric Flux Inference.Biophysical journal · 2019Article
- Review
- Mitochondrial health and muscle plasticity after spinal cord injury.European journal of applied physiology · 2019Review
- Age- and AD-related redox state of NADH in subcellular compartments by fluorescence lifetime imaging microscopy.GeroScience · 2019Article
- Self-Paced Free-Running Wheel Mimics High-Intensity Interval Training Impact on Rats' Functional, Physiological, Biochemical, and Morphological Features.Frontiers in physiology · 2019Article
- Searching for a mitochondrial root to the decline in muscle function with ageing.Journal of cachexia, sarcopenia and muscle · 2018Article
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loss of mitochondrial respiratory flux is a hallmark of skeletal muscle aging, contributing to a progressive decline of muscle strength. Endurance exercise alleviates the decrease in respiratory flux, both in humans and in rodents. Here, we dissect the underlying mechanism of mitochondrial flux decline by integrated analysis of the molecular network. Mice were given a lifelong ad libitum low-fat or high-fat sucrose diet and were further divided into sedentary and running-wheel groups. At 6, 12, 18 and 24 months, muscle weight, triglyceride content and mitochondrial respiratory flux were analysed. Subsequently, transcriptome was measured by RNA-Seq and proteome by targeted LC-MS/MS analysis with
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