ArticleActa pharmacologica Sinica2017
Hispidulin mediates apoptosis in human renal cell carcinoma by inducing ceramide accumulation.
Article in Acta pharmacologica Sinica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 19 papers.
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19 citing papers in PubMed, 40 citations in OpenAlex.
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- Anti-Proliferative and Anti-Migratory Activities of Hispidulin on Human Melanoma A2058 Cells.Biomolecules · 2021Article
- HMGCR inhibition stabilizes the glycolytic enzyme PKM2 to support the growth of renal cell carcinoma.PLoS biology · 2021Article
- The Effect of Hispidulin, a Flavonoid fromMolecules (Basel, Switzerland) · 2021Article
- Hispidulin exhibits potent anticancer activity in vitro and in vivo through activating ER stress in non‑small‑cell lung cancer cells.Oncology reports · 2020Article
- Isorhamnetin and Hispidulin fromFoods (Basel, Switzerland) · 2020Article
- Hispidulin Inhibits Mast Cell-Mediated Allergic Inflammation through Down-Regulation of Histamine Release and Inflammatory Cytokines.Molecules (Basel, Switzerland) · 2019Article
- Targeting the transcription factor receptor LXR to treat clear cell renal cell carcinoma: agonist or inverse agonist?Cell death & disease · 2019Article
- Hispidulin induces ER stress-mediated apoptosis in human hepatocellular carcinoma cells in vitro and in vivo by activating AMPK signaling pathway.Acta pharmacologica Sinica · 2019Article
- Quantitative analysis, pharmacokinetics and metabolomics study for the comprehensive characterization of the salt-processing mechanism of Psoraleae Fructus.Scientific reports · 2019Article
- Endoplasmic reticulum stress triggers Xanthoangelol-induced protective autophagy via activation of JNK/c-Jun Axis in hepatocellular carcinoma.Journal of experimental & clinical cancer research : CR · 2019Article
- MiR-206 inhibits proliferation, migration, and invasion of gastric cancer cells by targeting theOncoTargets and therapy · 2019Article
Corrections and comments
- Retraction · 2021-09-07Duplication of/in Image · Paper Mill · Plagiarism of Image · Unreliable Data · · see: https://docs.google.com/spreadsheets/d/13K6zoo2oSATsFlY7YGyvm2_Xs1jibs0RH4nKQP5y8DY/edit?usp=sharing
- Retracted
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hispidulin, a polyphenolic flavonoid extracted from the traditional Chinese medicinal plant S involucrata, exhibits anti-tumor effects in a wide array of human cancer cells, mainly through growth inhibition, apoptosis induction and cell cycle arrest. However, its precise anticancer mechanisms remain unclear. In this study, we investigated the molecular mechanisms that contribute to hispidulin-induced apoptosis of human clear-cell renal cell carcinoma (ccRCC) lines Caki-2 and ACHN. Hispidulin (10, 20 μmol/L) decreased the viability of ccRCC cells in dose- and time-dependent manners without affecting that of normal tubular epithelial cells. Moreover, hispidulin treatment dose-dependently increased the levels of cleaved caspase-8 and caspase-9, but the inhibitors of caspase-8 and caspase-9 only partly abrogated hispidulin-induced apoptosis, suggesting that hispidulin triggered apoptosis via both extrinsic and intrinsic pathways. Moreover, hispidulin treatment significantly inhibited the activity of sphingosine kinase 1 (SphK1) and consequently promoted ceramide accumulation, thus leading to apoptosis of the cancer cells, whereas pretreatment with K6PC-5, an activator of SphK1, or overexpression of SphK1 significantly attenuated the anti-proliferative and pro-apoptotic effects of hispidulin. In addition, hispidulin treatment dose-dependently activated ROS/JNK signaling and led to cell apoptosis. We further demonstrated in Caki-2 xenograft nude mice that injection of hispidulin (20, 40 mg·kg
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