Evidence map›Paper›PMID 29119739›Full record

ArticleJournal of Zhejiang University. Science. B

Fertility outcomes in infertile women with complex hyperplasia or complex atypical hyperplasia who received progestin therapy and in vitro fertilization.

Miao Li, Jia-Lun Song, Ying Zhao, She-Ling Wu, Hong-Bin Liu, Rong Tang, Lei Yan

Open access · bronzeAbstract read
In one paragraph

Article in Journal of Zhejiang University. Science. B. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Fertility regulatory potential ofSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Miao LiCenter for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250012, China.
Jia-Lun SongCenter for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250012, China.
Ying ZhaoCenter for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250012, China.
She-Ling WuCenter for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250012, China.
Hong-Bin LiuCenter for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250012, China.
Rong TangCenter for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250012, China.
Lei YanCenter for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250012, China.
Ministry of Education of the People's Republic of China · CNShandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate fertility and oncologic outcomes in women with complex hyperplasia (CH) or complex atypical hyperplasia (CAH) who received fertility-sparing therapy and in vitro fertilization (IVF). Endometrial carcinoma is the most common carcinoma of the female genital tract, and is associated with endometrial hyperplasia (EH) resulting from long-term unopposed estrogenic stimulation of the endometrium. EH is characterized by non-physiological proliferation of endometrium that results in glands with irregular shapes and varying sizes. The World Health Organization (WHO) classified it into four types: simple or complex hyperplasia with or without atypia. CH is characterized by glands with irregular outlines that demonstrate marked structural complexity and back-to-back crowding. Atypical hyperplasia designates a proliferation of glands exhibiting cytologic atypia, in which varying degrees of nuclear atypia and loss of polarity are present. It has been reported that high-dose progestin is safe and efficient for CAH or early-stage low-grade carcinoma for young women who desire fertility-preserving treatment. However, few studies have reported the differences of pregnancy outcomes between patients with CAH and CH, while those patients take a great proportion in people suffered from infertility. More studies about the outcome of IVF are needed. Our aim is to evaluate fertility and oncological outcomes in women with CH or CAH who received fertility-sparing therapy.

Indexed as

Fertility PreservationFertilization in VitroAdultCarcinomaEndometrial HyperplasiaEndometrial NeoplasmsEndometriumFemaleHumansInfertility, FemalePregnancyPregnancy OutcomeProgestinsProgestinsProgestin therapy; Endometrial hyperplasia; In vitro fertilization

Identifiers

PMID29119739
PMCPMC5696320
OpenAlexW2774968628

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.