ArticleInternational journal for numerical methods in biomedical engineering2018
A framework for designing patient-specific bioprosthetic heart valves using immersogeometric fluid-structure interaction analysis.
Article in International journal for numerical methods in biomedical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Impact of the Design of Aortic Bioprostheses on Valve Function: A Parametric Study.Annals of biomedical engineering · 2026Article
- Parameterized shape optimization of a bi-leaflet heart valved conduit for pediatric applications.Engineering with computers · 2026Article
- Article
- A Parametric Finite Element Analysis of Chick Embryo Aortic Valve Leaflet Biomechanics.Bioengineering (Basel, Switzerland) · 2026Article
- Graph Neural Network Surrogates for Contacting Deformable Bodies with Necessary and Sufficient Contact Detection.Computer methods in applied mechanics and engineering · 2026Article
- An open-source computational framework for immersed fluid-structure interaction modeling using FEBio and MFEM.Engineering with computers · 2026Article
- ValveFit: An analysis-suitable B-spline-based surface fitting framework for patient-specific modeling of tricuspid valves.Computer methods in applied mechanics and engineering · 2026Article
- In Silico and In Vitro Comparison of Seven Closed and Semi-Closed Leaflet Designs for Transcatheter Heart Valve Replacements.Bioengineering (Basel, Switzerland) · 2025Article
- Computational construction and design optimization of a novel tri-tube heart valve.Biomechanics and modeling in mechanobiology · 2025Article
- Algorithmic Generation of Parameterized Geometric Models of the Aortic Valve and Left Ventricle.Sensors (Basel, Switzerland) · 2024Article
- In Vitro Comparison of a Closed and Semi-closed Leaflet Design for Adult and Pediatric Transcatheter Heart Valves.Annals of biomedical engineering · 2024Article
- Three-dimensional modelling of aortic leaflet coaptation and load-bearing surfaces: in silico design of aortic valve neocuspidizations.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
- Automated shape and thickness optimization for non-matching isogeometric shells using free-form deformation.Engineering with computers · 2024Article
- Parameterization, algorithmic modeling, and fluid-structure interaction analysis for generative design of transcatheter aortic valves.Engineering with computers · 2024Article
- Current progress toward isogeometric modeling of the heart biophysics.Biophysics reviews · 2023Review
- Strategies for Development of Synthetic Heart Valve Tissue Engineering Scaffolds.Progress in materials science · 2023Article
- Functional mechanical behavior of the murine pulmonary heart valve.Scientific reports · 2023Article
- A parametric geometry model of the aortic valve for subject-specific blood flow simulations using a resistive approach.Biomechanics and modeling in mechanobiology · 2023Article
- Analysis of the Effect of Thickness on the Performance of Polymeric Heart Valves.Journal of functional biomaterials · 2023Article
- Perfect prosthetic heart valve: generative design with machine learning, modeling, and optimization.Frontiers in bioengineering and biotechnology · 2023Article
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Authors and funding
9 authors.
Funding
Abstract
Numerous studies have suggested that medical image derived computational mechanics models could be developed to reduce mortality and morbidity due to cardiovascular diseases by allowing for patient-specific surgical planning and customized medical device design. In this work, we present a novel framework for designing prosthetic heart valves using a parametric design platform and immersogeometric fluid-structure interaction (FSI) analysis. We parameterize the leaflet geometry using several key design parameters. This allows for generating various perturbations of the leaflet design for the patient-specific aortic root reconstructed from the medical image data. Each design is analyzed using our hybrid arbitrary Lagrangian-Eulerian/immersogeometric FSI methodology, which allows us to efficiently simulate the coupling of the deforming aortic root, the parametrically designed prosthetic valves, and the surrounding blood flow under physiological conditions. A parametric study is performed to investigate the influence of the geometry on heart valve performance, indicated by the effective orifice area and the coaptation area. Finally, the FSI simulation result of a design that balances effective orifice area and coaptation area reasonably well is compared with patient-specific phase contrast magnetic resonance imaging data to demonstrate the qualitative similarity of the flow patterns in the ascending aorta.
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