ReviewBiological reviews of the Cambridge Philosophical Society2018
Tick attachment cement - reviewing the mysteries of a biological skin plug system.
Review in Biological reviews of the Cambridge Philosophical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 76 citations in OpenAlex.
- Spotted fever group Rickettsia infection kinetics and cutaneous host response during single tick feeding events.PLoS pathogens · 2026Article
- NETosis mediates tick blood pool formation.The Journal of veterinary medical science · 2026Article
- Arthropod exosomal glycine-rich protein as a potential vaccine candidate effectively reduces tick blood-feeding and pathogen transmission.The EMBO journal · 2026Article
- Tick-Borne Encephalitis in the 21Le infezioni in medicina · 2026Review
- Surgical Removal of a Tick-Bite Region Without the Presence of an Insect Body.Clinical case reports · 2025Article
- Tick feeding or vaccination with tick antigens elicits immunity to theScience translational medicine · 2025Article
- Phase separation and ageing of glycine-rich protein from tick adhesive.Nature chemistry · 2025Article
- In silico screening and immunogenic features of putative tick cement protein PA107 from Ixodes ricinus tick.Experimental & applied acarology · 2025Article
- Editorial: Skin - confluence of vertebrate host defences, arthropod vectors, and vector-borne pathogens.Frontiers in immunology · 2025Article
- Transcriptomic landscapes reveal development-related physiological processes in the two-spotted spider mite, Tetranychus urticae.Experimental & applied acarology · 2024Article
- GW4869 inhibitor affects vector competence and tick-borne flavivirus acquisition and transmission by blocking exosome secretion.iScience · 2024Article
- Hard Ticks as Vectors: The Emerging Threat of Tick-Borne Diseases in India.Pathogens (Basel, Switzerland) · 2024Review
- Review
- Human Tick-Borne Diseases and Advances in Anti-Tick Vaccine Approaches: A Comprehensive Review.Vaccines · 2024Review
- Tick extracellular vesicles in host skin immunity and pathogen transmission.Trends in parasitology · 2023Review
- Seasonal Dynamics and Physiological Age of Ixodid Ticks Collected from Dogs.Animals : an open access journal from MDPI · 2023Article
- Tick saliva and its role in pathogen transmission.Wiener klinische Wochenschrift · 2023Article
- Recent Advances in Tick Antigen Discovery and Anti-Tick Vaccine Development.International journal of molecular sciences · 2023Review
- Identification and characterization of proteins that form the inner core Ixodes scapularis tick attachment cement layer.Scientific reports · 2022Article
- A contrivance of tick removal to prevent skin damage: Injection into the tick before removal.Journal of Taibah University Medical Sciences · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The majority of ticks in the family Ixodidae secrete a substance anchoring their mouthparts to the host skin. This substance is termed cement. It has adhesive properties and seals the lesion during feeding. The particular chemical composition and the curing process of the cement are unclear. This review summarizes the literature, starting with a historical overview, briefly introducing the different hypotheses on the origin of the adhesive and how the tick salivary glands have been identified as its source. Details on the sequence of cement deposition, the curing process and detachment are provided. Other possible functions of the cement, such as protection from the host immune system and antimicrobial properties, are presented. Histochemical and ultrastructural data of the intracellular granules in the salivary gland cells, as well as the secreted cement, suggest that proteins constitute the main material, with biochemical data revealing glycine to be the dominant amino acid. Applied methods and their restrictions are discussed. Tick cement is compared with adhesives of other animals such as barnacles, mussels and sea urchins. Finally, we address the potential of tick cement for the field of biomaterial research and in particular for medical applications in future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.