Evidence map›Paper›PMID 29119630›Full record

ArticleProtein science : a publication of the Protein Society2018

Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein.

Jan Abendroth, Andrew Frando, Isabelle Q Phan, Bart L Staker, Peter J Myler, Thomas E Edwards, Christoph Grundner

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Structural diversity in the Mycobacteria DUF3349 superfamily.Protein science : a publication of the Protein Society · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jan AbendrothBeryllium Discovery, Bainbridge Island, Washington.
Andrew FrandoCenter for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington.
Isabelle Q PhanSeattle Structural Genomics Center for Infectious Disease, Seattle, Washington.
Bart L StakerSeattle Structural Genomics Center for Infectious Disease, Seattle, Washington.
Peter J MylerSeattle Structural Genomics Center for Infectious Disease, Seattle, Washington.
Thomas E EdwardsBeryllium Discovery, Bainbridge Island, Washington.
Christoph GrundnerCenter for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington.
Center for Infectious Disease Research · USBeryllium (United States) · US

Funding

INTERDISCIPLINARY PROGRAM IN BACTERIAL PATHOGENESIST32AI055396 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2003 to 2019
$2.8M
The role of Ser/Thr/Tyr phosphosignaling in the M. tuberculosis latency switchR01AI117023 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI GRUNDNER, CHRISTOPH · 2016 to 2020
$2.4M
NIAID NIH HHS HHSN272201200025CNIAID NIH HHS R01 AI117023NIAID NIH HHS T32 AI055396
6 · The paper itself

Abstract

The genome of the human pathogen Mycobacterium tuberculosis (Mtb) encodes ∼4,400 proteins, but one third of them have unknown functions. We solved the crystal structure of Rv3651, a hypothetical protein with no discernible similarity to proteins with known function. Rv3651 has a three-domain architecture that combines one cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA (GAF) domain and two Per-ARNT-Sim (PAS) domains. GAF and PAS domains are sensor domains that are typically linked to signaling effector molecules. Unlike these sensor-effector proteins, Rv3651 is an unusual sensor domain-only protein with highly divergent sequence. The structure suggests that Rv3651 integrates multiple different signals and serves as a scaffold to facilitate signal transfer.

Indexed as

Bacterial ProteinsCrystallography, X-RayModels, MolecularMycobacterium tuberculosisProtein BindingProtein DomainsProtein Structure, SecondaryProtein Structure, TertiaryBacterial ProteinsCRP protein, Mycobacterium tuberculosisGAF domainMycobacterium tuberculosisPAS domainproteins of unknown function

Identifiers

PMID29119630
PMCPMC5775179
OpenAlexW2777052253

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.