Trial reportClinical rheumatology2018
Low-level laser therapy for xerostomia in primary Sjögren's syndrome: a randomized trial.
Trial report in Clinical rheumatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Comparative efficacy and safety of non-pharmacological interventions on treatment-induced xerostomia in head and neck cancer patients: a systematic review and network meta-analysis.Frontiers in oncology · 2025Pooled it
- Effects of low-level light therapy on xerostomia related to hyposalivation: a systematic review and meta-analysis of clinical trials.Lasers in medical science · 2022Pooled it
- Photobiomodulation and salivary glands: a systematic review.Lasers in medical science · 2020Pooled it
- Laser Acupuncture on the Management of Xerostomia in Sjögren's Disease: A Randomized Clinical Trial.Oral diseases · 2026Trial
- Low-level laser and transcutaneous electrical nerve stimulation on salivary glands impact type 2 diabetes mellitus oral microbiome: an interim analysis of a randomized trial.Lasers in medical science · 2025Trial
- Reliability of the electronic patient reported outcome measures for assessing xerostomia, dysphagia and quality of life in Spanish patients with head and neck cancer: a randomised crossover design.Health and quality of life outcomes · 2025Trial
- Effects of photobiomodulation in salivary glands of chronic kidney disease patients on hemodialysis.Lasers in medical science · 2021Trial
- Photobiomodulation for salivary gland dysfunction: aligning clinical expectations with etiology-dependent treatment responsiveness.Lasers in medical science · 2026Review
- Effectiveness of photobiomodulation in the treatment of xerostomia in type II diabetic patients.Odontology · 2026Article
- Age-specific reference values for unstimulated whole saliva flow rate in primary Sjögren's syndrome: a cross-sectional study.BMC oral health · 2026Article
- The state of the art of oral lesions in HTLV-1 infection.Odontology · 2026Review
- Diode-laser-assisted biopsy and photobiomodulation therapy in the management of Sjögren's disease: a case report.Journal of medical case reports · 2026Article
- Commentary: Comparative efficacy and safety of non-pharmacological interventions on treatment-induced xerostomia in patients with head and neck cancer: a systematic review and network meta-analysis.Frontiers in oncology · 2026Article
- Photobiomodulation in the management of oral lesions: a targeted, evidence-based approach.Brazilian oral research · 2026Review
- Photobiomodulation therapy for salivary gland hypofunction: a preliminary human study.Lasers in medical science · 2025Article
- Article
- Evaluation of the Effect of Photobiomodulation on Radiation-Induced Xerostomia in Head and Neck Cancer Patients: A Randomized Clinical Trial.Journal of lasers in medical sciences · 2024Article
- The Photobiomodulation effect of 980 nm Diode Laser on Patients with Xerostomia.Lasers in medical science · 2023Article
- A scoping review on hyposalivation associated with systemic conditions: the role of physical stimulation in the treatment approaches.BMC oral health · 2023Article
- Treatment alternatives for dry mouth: A scoping review.Journal of clinical and experimental dentistry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate the effectiveness of low-level laser therapy (LLLT) in the treatment of xerostomia in primary Sjögren's syndrome (SS), a randomized clinical trial of patients with dry mouth symptoms associated with primary SS receiving care at a university hospital was conducted. Sixty-six patients were randomly assigned with a 1:1 allocation ratio to receive LLLT (laser group, n = 33) or placebo treatment (placebo group, n = 33). Patients in the laser group received LLLT twice a week for 6 weeks, for a total of 12 treatment sessions. Laser irradiation was performed with an aluminum-gallium-arsenide laser diode at a wavelength of 808 nm, 100-mW output power, and energy density of 4.0 J/cm
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.