Evidence map›Paper›PMID 29119386›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2018

Endovascular Ischemic Stroke Models in Nonhuman Primates.

Di Wu, Ankush Chandra, Jian Chen, Yuchuan Ding, Xunming Ji

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Non-human primate models of focal cortical ischemia for neuronal replacement therapy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Review
  5. Review
  6. Review
  7. Intranasal salvinorin A improves neurological outcome in rhesus monkey ischemic stroke model using autologous blood clot.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  8. Article
  9. Reperfusion plus Selective Intra-arterial Cooling (SI-AC) Improve Recovery in a Nonhuman Primate Model of Stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Article
  10. Article
  11. Selective intra-arterial brain cooling improves long-term outcomes in a non-human primate model of embolic stroke: Efficacy depending on reperfusion status.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Di WuChina-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China.
Ankush ChandraDepartment of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, USA.
Jian ChenChina-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yuchuan DingChina-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China.
Xunming JiChina-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China. jixm@ccmu.edu.cn.
Capital Medical University · CNUniversity of California, San Francisco · USWayne State University · US

Funding

Chang Jiang Scholars Program T2014251National Key R & D Program of China 2017YFC1308401National Natural Science Foundation of China 81325007National Natural Science Foundation of China 81500997National Natural Science Foundation of China 81620108011National Natural Science Foundation of China 81771260The "mission" talent project of Beijing Municipal Administration of Hospitals SML20150802
6 · The paper itself

Abstract

To bridge the gap between rodent and human studies, the Stroke Therapy Academic Industry Roundtable committee suggests that nonhuman primates (NHPs) be used for preclinical, translational stroke studies. Owing to the fact that vast majority of ischemic strokes are caused by transient or permanent occlusion of a cerebral blood vessel eventually leading to brain infarction, ischemia induced by endovascular methods closely mimics thromboembolic or thrombotic cerebrovascular occlusion in patients. This review will make a thorough summary of transient or permanent occlusions of a cerebral blood vessel in NHPs using endovascular methods. Then, advantages and disadvantages, and potential applications will be analyzed for each kind of models. Additionally, we also make a further analysis based on different kinds of emboli, various occlusion sites, infract size, abnormal hemodynamics, and potential dysfunctions. Experimental models of ischemic stroke in NHPs are valuable tools to analyze specific facets of stroke in patients, especially those induced by endovascular methods.

Indexed as

Disease Models, AnimalAnimalsBrain IschemiaEndovascular ProceduresInfarction, Middle Cerebral ArteryMacaca fascicularisMacaca mulattaStrokeTranslational Research, Biomedicalanimal modelIschemic strokenonhuman primateprognosisthrombolysis

Identifiers

PMID29119386
PMCPMC5794699
OpenAlexW2767582598

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.