Evidence map›Paper›PMID 29119301›Full record

Trial reportEuropean child & adolescent psychiatry2018

Whole body vibration added to treatment as usual is effective in adolescents with depression: a partly randomized, three-armed clinical trial in inpatients.

Heidrun Lioba Wunram, Stefanie Hamacher, Martin Hellmich, Maxi Volk, Franziska Jänicke, Franziska Reinhard, Wilhelm Bloch, Philipp Zimmer, Christine Graf, Eckhard Schönau and 3 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European child & adolescent psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  19. [The German S3 guideline for depressive disorders in childhood and adolescence: new developments].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Heidrun Lioba WunramDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Cologne, Cologne, Germany. heidrun-lioba.wunram@uk-koeln.de.
Stefanie HamacherDepartment of Medical Statistics and Computational Biology (IMSB), University of Cologne, Cologne, Germany.
Martin HellmichDepartment of Medical Statistics and Computational Biology (IMSB), University of Cologne, Cologne, Germany.
Maxi VolkDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Cologne, Cologne, Germany.
Franziska JänickeDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Cologne, Cologne, Germany.
Franziska ReinhardDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Cologne, Cologne, Germany.
Wilhelm BlochDepartment for Molecular and Cellular Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany.
Philipp ZimmerDepartment for Molecular and Cellular Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany.
Christine GrafInstitute of Movement and Neuroscience, German Sport University Cologne, Cologne, Germany.
Eckhard SchönauChildren's Hospital, University Hospital of Cologne, Cologne, Germany.
Gerd LehmkuhlDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Cologne, Cologne, Germany.
Stephan BenderDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Cologne, Cologne, Germany.
Oliver FrickeDepartment of Child and Adolescent Psychiatry, Psychotherapy and Child Neurology, Gemeinschaftskrankenhaus Herdecke and Chair of Child and Adolescent Psychiatry, Witten/Herdecke University, Witten, Germany.

Funding

Marga und Walter Boll Foundation 210-07.2-11
6 · The paper itself

Abstract

There is growing evidence for the effectiveness of exercise in the treatment of adult major depression. With regard to adolescents, clinical trials are scarce. Due to the inherent symptoms of depression (lack of energy, low motivation to exercise), endurance training forms could be too demanding especially in the first weeks of treatment. We hypothesized that an easy-to-perform passive muscular training on a whole body vibration (WBV) device has equal anti-depressive effects compared to a cardiovascular training, both administered as add-ons to treatment as usual (TAU). Secondly, we presumed that both exercise interventions would be superior in their response, compared to TAU. In 2 years 64 medication-naïve depressed inpatients aged 13-18, were included. Both exercise groups fulfilled a supervised vigorous training for 6 weeks. Depressive symptoms were assessed by self-report ("Depressions Inventar für Kinder und Jugendliche"-DIKJ) before intervention and after weeks 6, 14 and 26. Compared to TAU, both groups responded earlier and more strongly measured by DIKJ scores, showing a trend for the WBV group after week 6 (p = 0.082). The decrease became statistically significant for both intervention groups after week 26 (p = 0.037 for ergometer and p = 0.042 for WBV). Remission rates amounted to 39.7% after week 6 and 66% after week 26, compared to 25% after week 26 in TAU. These results provide qualified support for the effectiveness of exercise as add-on treatment for medication-naïve depressed adolescents. The present results are limited by the not randomized control group.

Indexed as

AdolescentChildDepressionExerciseFemaleHumansInpatientsMaleVibrationAdolescentsDepressionExercisePhysical activitySportsWhole body vibration

Identifiers

PMID29119301

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.