ArticleInternational journal of colorectal disease2018
Local antibiotic decontamination to prevent anastomotic leakage short-term outcome in rectal cancer surgery.
Article in International journal of colorectal disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
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Who cites it
16 citing papers in PubMed.
- Prevention of anastomotic leak in rectal cancer surgery with local antibiotic decontamination: a prospective, randomized, double-blind, placebo-controlled single center trial.International journal of colorectal disease · 2020Trial
- Article
- Successful Clinical Avoidance of Colorectal Anastomotic Leakage through Local Decontamination.Antibiotics (Basel, Switzerland) · 2024Article
- The Influence of the Microbiome on Anastomotic Leak.Clinics in colon and rectal surgery · 2023Review
- Anastomotic leakage in rectal cancer surgery: Retrospective analysis of risk factors.World journal of clinical cases · 2022Article
- It is not NOD2 - genetic and clinical risk factors for postoperative complications following ileocolic resection in Crohn's disease.International journal of colorectal disease · 2022Article
- Antibiotic Bowel Decontamination in Gastrointestinal Surgery-A Single-Center 20 Years' Experience.Frontiers in surgery · 2022Article
- Current Insights: The Impact of Gut Microbiota on Postoperative Complications in Visceral Surgery-A Narrative Review.Diagnostics (Basel, Switzerland) · 2021Review
- Anastomotic Leak: Toward an Understanding of Its Root Causes.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Review
- Influence of the Microbiome on Anastomotic Leak.Clinics in colon and rectal surgery · 2021Review
- The gut microbiota and colorectal surgery outcomes: facts or hype? A narrative review.BMC surgery · 2021Review
- Reinforcement of Colonic Anastomosis with Improved Ultrafine Nanofibrous Patch: Experiment on Pig.Biomedicines · 2021Article
- Selective Intestinal Decontamination as a Method for Preventing Infectious Complications (Review).Sovremennye tekhnologii v meditsine · 2021Review
- Involvement of the Commensal OrganismSurgical infections · 2020Article
- The use of oral antibiotics and mechanical bowel preparation in elective colorectal resection for the reduction of surgical site infection.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2020Article
- [Oral antibiotic prophylaxis for bowel decontamination before elective colorectal surgery : Current body of evidence and recommendations].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAnastomotic leakage still presents an issue in rectal cancer surgery with rates of about 11%. As bacteria play a critical role, there is the concept of perioperative local decontamination to prevent anastomotic leakage.
methodsTo ascertain the effectiveness of this treatment, we performed a retrospective analysis on 206 rectal resections with primary anastomosis and routine use of a selective decontamination of the digestive tract (SDD) regimen for local decontamination. SDD medication was administered every 8 h from the day before surgery to the seventh postoperative day. All patients were treated according to the fast-track protocol without mechanical bowel preparation; instead, a laxative was used.
resultsOverall morbidity was 30%, overall mortality 0.5%. In our data, overall rate of anastomotic leakage (AL) was 5.8%, with 3.9% in anterior rectal resection and 6.5% in low anterior rectal resection group. In 75% of cases, anastomotic leakage was grade "C" and needed re-laparotomy. Surgical site infection rate was 19.9%. No serious adverse events were related to decontamination.
conclusionLocal antibiotic decontamination appears to be safe and effective to decrease the rate of anastomotic leakage in rectal cancer surgery. Further focus should be on perioperative management including bowel preparation and choice of antimicrobial agents for local decontamination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.