Wnt and Hedgehog Signaling Regulate the Differentiation of F9 Cells into Extraembryonic Endoderm.

Gurjoth S J Deol, Tina N Cuthbert, Mohamed I Gatie, Danielle M Spice, Lindsay R Hilton, Gregory M Kelly

Open access · goldAbstract read

In one paragraph

Article in Frontiers in cell and developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

0.4field-weighted citation impact, top 36% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

In silico discovery of small molecules for efficient stem cell differentiation into definitive endoderm.Stem cell reports · 2023
Article
Optimization of activin-A: a breakthrough in differentiation of human induced pluripotent stem cell into definitive endoderm.3 Biotech · 2020
Article
The Role of Hedgehog Signalling in the Formation of the Ventricular Septum.Journal of developmental biology · 2017
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Gurjoth S J DeolMolecular Genetics Unit, Department of Biology, University of Western Ontario, London, ON, Canada.

Tina N CuthbertMolecular Genetics Unit, Department of Biology, University of Western Ontario, London, ON, Canada.

Mohamed I GatieMolecular Genetics Unit, Department of Biology, University of Western Ontario, London, ON, Canada.

Danielle M SpiceMolecular Genetics Unit, Department of Biology, University of Western Ontario, London, ON, Canada.

Lindsay R HiltonMolecular Genetics Unit, Department of Biology, University of Western Ontario, London, ON, Canada.

Gregory M KellyMolecular Genetics Unit, Department of Biology, University of Western Ontario, London, ON, Canada.

Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mouse F9 cells differentiate into primitive extraembryonic endoderm (PrE) when treated with retinoic acid (RA), and this is accompanied by an up-regulation of

Indexed as

extraembryonic endoderm formationHedgehogretinoic acidWnt

Identifiers

PMID29119099

DOI10.3389/fcell.2017.00093

PMCPMC5660979

OpenAlexW2766385207

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.