Evidence map›Paper›PMID 29119056›Full record

ArticleAmerican journal of cancer research2017

Downregulation of cyclin-dependent kinase 8 by microRNA-148a suppresses proliferation and invasiveness of papillary thyroid carcinomas.

Chun Han, Weihui Zheng, Minghua Ge, Kejing Wang, Yangfeng Xiang, Peng Wang

Open access · greenAbstract read
In one paragraph

Article in American journal of cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chun HanDepartment of Head & Neck Surgery, Zhejiang Cancer HospitalHangzhou 310022, China.
Weihui ZhengDepartment of Head & Neck Surgery, Zhejiang Cancer HospitalHangzhou 310022, China.
Minghua GeDepartment of Head & Neck Surgery, Zhejiang Cancer HospitalHangzhou 310022, China.
Kejing WangDepartment of Head & Neck Surgery, Zhejiang Cancer HospitalHangzhou 310022, China.
Yangfeng XiangDepartment of Head & Neck Surgery, Zhejiang Cancer HospitalHangzhou 310022, China.
Peng WangDepartment of Head & Neck Surgery, Zhejiang Cancer HospitalHangzhou 310022, China.
Zhejiang Cancer Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are important gene regulators that play key roles in tumor genesis. In this study, we investigate the role of miR-148a in the development of papillary thyroid cancer (PTC). Data from the cancer genome atlas (TCGA) indicate that miR-148a is downregulated in PTC tissues; we also find that miR-148a is downregulated in tissue samples from PTC patients and PTC cell lines. Overexpression of miR-148a significantly suppresses PTC cell proliferation, migration and invasiveness

Indexed as

cyclin-dependent kinase 8 (CDK8)metastasismiR-148apapillary thyroid carcinoma (PTC)proliferation

Identifiers

PMID29119056
PMCPMC5665854
OpenAlexW3021416382

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.