ArticleGastroenterology and hepatology from bed to bench2017
A systems biology analysis protein-protein interaction of NASH and IBD based on comprehensive gene information.
Article in Gastroenterology and hepatology from bed to bench, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 33 citations in OpenAlex.
- Characterizing Non-T2 Asthma: Key Pathways and Molecular Implications Indicative of Attenuated Th2 Response.Inflammation · 2025Article
- Molecular mechanism detection of stage I to stage II transition of esophageal squamous cell carcinoma: a system biology approach.Gastroenterology and hepatology from bed to bench · 2024Article
- Assessment of Photosensitizer Concentration Effects on the Efficacy of Photodynamic Therapy.Journal of lasers in medical sciences · 2023Article
- Prediction of Genes Involved in Lung Cancer with a Systems Biology Approach Based on Comprehensive Gene Information.Biochemical genetics · 2022Review
- Crystallographic mining of ASK1 regulators to unravel the intricate PPI interfaces for the discovery of small molecule.Computational and structural biotechnology journal · 2022Review
- Down-regulation of TP53 is a highlighted molecular event in gastric ulcer.Gastroenterology and hepatology from bed to bench · 2022Article
- Role of Lymphotoxin-α Gene Polymorphism in Hepatitis C Virus-Related Chronic Liver Disorders.Infection and drug resistance · 2021Article
- UNaProd: A Universal Natural Product Database forEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Role of Flt4 in Skin Protection against UVB Radiation: A System Biology Approach.Journal of lasers in medical sciences · 2020Article
- The developmental origins of sex-biased expression in cardiac development.Biology of sex differences · 2019Article
- Qianggan extract improved nonalcoholic steatohepatitis by modulating lncRNA/circRNA immune ceRNA networks.BMC complementary and alternative medicine · 2019Article
- Nasopharyngeal Carcinoma Protein Interaction Mapping Analysis via Proteomic ApproachesAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Fibroblast-myofibroblast crosstalk after exposure to mesenchymal stem cells secretome.Gastroenterology and hepatology from bed to bench · 2018Article
- Inducible nitric oxide synthase as a potential blood-based biomarker in inflammatory bowel diseases.Gastroenterology and hepatology from bed to bench · 2018Article
- Network analysis of grade II into grade III transition in rectum cancer patients.Gastroenterology and hepatology from bed to bench · 2018Article
- Comparing different non-invasive methods in assessment of the effects of curcumin on hepatic fibrosis in patients with non-alcoholic fatty liver disease.Gastroenterology and hepatology from bed to bench · 2018Article
- Protein-Protein Interaction Network Analysis Revealed a New Prospective of Posttraumatic Stress Disorder.Galen medical journal · 2018Article
- Protein-protein interaction analysis of Alzheimer`s disease and NAFLD based on systems biology methods unhide common ancestor pathways.Gastroenterology and hepatology from bed to bench · 2018Article
- Evaluation of GKN1 and GKN2 gene expression as a biomarker of gastric cancer.Gastroenterology and hepatology from bed to bench · 2018Article
- The high frequency of esophageal disorders in Iranian patients with non-cardiac chest pain.Gastroenterology and hepatology from bed to bench · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimAnalysis reconstruction networks from two diseases, IBD and NASH and their relationship, based on systems biology methods.
backgroundIBD and NASH are two complex diseases, with progressive prevalence and high cost for countries. There are some reports on co-existence of these two diseases. In addition, they have some similar risk factors such as age, obesity, and insulin resistance. Therefore, systems biology approach can help to discover their relationship.
methodsDisGeNET and STRING databases were sources of disease genes and constructing networks. Three plugins of Cytoscape software, including ClusterONE, ClueGO and CluePedia, were used to analyze and cluster networks and enrichment of pathways. Based on degree and Betweenness, hubs and bottleneck nodes were defined.
resultsCommon genes between IBD and NASH construct a network with 99 nodes. Common genes between IBD and NASH were extracted and imported to STRING database to construct PPI network. The resulting network contained 99 nodes and 333 edges. Five genes were selected as hubs: JAK2, TLR2, TP53, TLR4 and STAT3 and five genes were selected as bottleneck including: JAK2, TP53, AGT, CYP3A4 and TLR4. These genes were hubs in analysis network that was constructed from hubs of NASH and IBD networks.
conclusionSystems biology methods, specifically PPI networks, can be useful for analyzing complicated related diseases. Finding Hub and bottleneck proteins should be the goal of drug designing and introducing disease markers.
Indexed as
Identifiers
29118935PMC5660269W2754645765What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.