ArticleAmerican journal of translational research2017
Resveratrol improves neuron protection and functional recovery through enhancement of autophagy after spinal cord injury in mice.
Article in American journal of translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Natural Products and Neuroregeneration: Rethinking Discovery Beyond Bioavailability Through Pseudo-Natural Product Design.Biomedicines · 2026Review
- Resveratrol and neuroprotection: modulation of cellular dynamics and signaling networks in neurodegenerative diseases.Inflammopharmacology · 2026Review
- Investigating the neurological function and anti-inflammatory effects of resveratrol in small mammal spinal cord injury models: A systematic review and meta-analysis.Surgical neurology international · 2026Review
- NEMO-Binding Domain/IKKγ Inhibitory Peptide Alleviates Neuronal Pyroptosis in Spinal Cord Injury by Inhibiting ASMase-Induced Lysosome Membrane Permeabilization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Tomatidine relieves neuronal damage in spinal cord injury by inhibiting the inflammatory responses and apoptosis through blocking the NF-κB/CXCL10 pathway activation.Frontiers in pharmacology · 2024Article
- The Roles of Caloric Restriction Mimetics in Central Nervous System Demyelination and Remyelination.Current issues in molecular biology · 2023Review
- A review of mechanisms underlying the protective effects of natural compounds against arsenic-induced neurotoxicity.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Review
- Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization.Journal of neuroinflammation · 2023Article
- 3,4-Dimethoxychalcone, a caloric restriction mimetic, enhances TFEB-mediated autophagy and alleviates pyroptosis and necroptosis after spinal cord injury.Theranostics · 2023Article
- Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision.Oxidative medicine and cellular longevity · 2022Review
- Therapeutic Effects of Resveratrol on Ischemia-Reperfusion Injury in the Nervous System.Neurochemical research · 2021Review
- Therapeutic Applications of Resveratrol in Hepatic Encephalopathy through Its Regulation of the Microbiota, Brain Edema, and Inflammation.Journal of clinical medicine · 2021Review
- AAV2-mediated and hypoxia response element-directed expression of bFGF in neural stem cells showed therapeutic effects on spinal cord injury in rats.Cell death & disease · 2021Article
- Resveratrol Inhibits Venezuelan Equine Encephalitis Virus Infection by Interfering with the AKT/GSK Pathway.Plants (Basel, Switzerland) · 2021Article
- Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway.International journal of biological sciences · 2021Article
- Natural Compounds and Autophagy: Allies Against Neurodegeneration.Frontiers in cell and developmental biology · 2020Review
- Mechanism of tauroursodeoxycholic acid-mediated neuronal protection after acute spinal cord injury through AKT signaling pathway in rats.International journal of clinical and experimental pathology · 2020Article
- Jia-Ji Electro-Acupuncture Improves Locomotor Function With Spinal Cord Injury by Regulation of Autophagy Flux and Inhibition of Necroptosis.Frontiers in neuroscience · 2020Article
- Resveratrol Restores Neuronal Tight Junction Proteins Through Correction of Ammonia and Inflammation in CClMolecular neurobiology · 2019Article
- Neuroprotective effects of rapamycin on spinal cord injury in rats by increasing autophagy and Akt signaling.Neural regeneration research · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resveratrol (Res), a natural phenolic compound, has been proven to have a wide variety of beneficial health effects. For example, resveratrol has neuroprotective effects in different central nervous system diseases. However, the mechanisms underlying resveratrol neuroprotection in spinal cord injury (SCI) remain unclear. In this study, we showed that resveratrol treatment improved the restoration of locomotor function, and decreased the degeneration of neurons in SCI mice, which was paralleled by a reduction of apoptosis. We further examined autophagy markers via western blot and immunofluorescence. Results showed that the beneficial effects of resveratrol were related to the promotion LC3II and beclin-1 expression. In addition, autophagy suppression with chloroquine (CQ) partially abolished apoptosis inhibition and locomotor functional improvement of Res on SCI, which indicated that the beneficial effect of resveratrol on SCI was through autophagy enhancement. In conclusion, these results illustrated that the neuroprotective effects of resveratrol in SCI are partially through autophagy stimulation, and implied that Res is a promising drug for SCI therapy.
Indexed as
Identifiers
29118921PMC5666068W2913766732What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.