Evidence map›Paper›PMID 29118906›Full record

ArticleAmerican journal of translational research2017

RNAi-mediated silencing of NOX4 inhibited the invasion of gastric cancer cells through JAK2/STAT3 signaling.

Xiang Gao, Jingping Sun, Chunyu Huang, Xiaohua Hu, Ning Jiang, Chenqi Lu

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. NOX Family: Regulators of Reactive Oxygen Species Balance in Tumor Cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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  11. Overexpression ofGland surgery · 2022
    Article
  12. Review
  13. Article
  14. Inhibiting the Activity of NADPH Oxidase in Cancer.Antioxidants & redox signaling · 2020
    Article
  15. Review
  16. Article
  17. BioMed research international · 2020
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Xiang GaoDepartment of Biostatistics and Computational Biology, SKLG, School of Life Sciences, Fudan UniversityShanghai, China.
Jingping SunThe First People's Hospital of Wujiang DistrictSuzhou, Jiangsu, China.
Chunyu HuangGenergy Bio-technology (Shanghai) Co., LTDRoom 4B, Building#3, No. 401 Caobao Rd, Xuhui District, Shanghai, China.
Xiaohua HuDepartment of Biostatistics and Computational Biology, SKLG, School of Life Sciences, Fudan UniversityShanghai, China.
Ning JiangDepartment of Biostatistics and Computational Biology, SKLG, School of Life Sciences, Fudan UniversityShanghai, China.
Chenqi LuDepartment of Biostatistics and Computational Biology, SKLG, School of Life Sciences, Fudan UniversityShanghai, China.
Fudan University · CNShanghai Genon Biological Products (China) · CNWujiang District People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NADPH oxidase 4 (NOX4) is a member of the NADPH oxidase (NOX) family of enzymes and has been found abnormally expressed in human cancers. However, its role in gastric cancer (GC) is still unclear. In the current study, we reported that NOX4 expression levels were significantly up-regulated in GC tissues compared to normal tissues (

Indexed as

epithelial-mesenchymal transitioninvasionJAK2NOX4STAT3

Identifiers

PMID29118906
PMCPMC5666053
OpenAlexW2971256370

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.