ReviewAmerican journal of translational research2017
Alterations in tendon microenvironment in response to mechanical load: potential molecular targets for treatment strategies.
Review in American journal of translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed.
- Eccentric Training for Tendinopathies in Athletes: A Scoping Review and Evidence Gap Map.Journal of sports science & medicine · 2026Article
- Tendinopathy: The Interplay between Mechanical Stress, Inflammation, and Vascularity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Epigenetic regulation and mechanobiological adaptation in tenocytes during maturation.APL bioengineering · 2025Article
- AMP-activated protein kinase (AMPK) is essential for tendon homeostasis and prevents premature senescence and ectopic calcification.bioRxiv : the preprint server for biology · 2025Article
- Dexamethasone treatment influences tendon healing through altered resolution and a direct effect on tendon cells.Scientific reports · 2024Article
- Review
- Risk factors for incisional hernia after gastrointestinal surgeries in non-tumor patients.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- Biologically Enhanced Patch in the Healing and Mechanical Stability of Rotator Cuff Tears.Journal of biotechnology and biomedicine · 2024Article
- Hyperlipidemia Induced Pathological Changes with no Effect in Biomechanical Properties in the Achilles Tendon of Young Swine.Journal of orthopaedics and sports medicine · 2024Article
- Review
- Incidence, risk factors, and predictive modeling of stoma site incisional hernia after enterostomy closure: a multicenter retrospective cohort study.BMC gastroenterology · 2023Article
- Single-cell and spatial transcriptomics reveal changes in cell heterogeneity during progression of human tendinopathy.BMC biology · 2023Article
- Hyperlipidemia Lowers the Biomechanical Properties of Rotator Cuff Tendon.Journal of orthopaedics and sports medicine · 2023Article
- Biomechanical Forces in the Tissue Engineering and Regeneration of Shoulder, Hip, Knee, and Ankle Joints.Journal of biotechnology and biomedicine · 2023Article
- Bioactive extracellular matrix fragments in tendon repair.Cell and tissue research · 2022Review
- Age-related cellular and microstructural changes in the rotator cuff enthesis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- The role of loading in murine models of rotator cuff disease.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Rotator Cuff Health, Pathology, and Repair in the Perspective of Hyperlipidemia.Journal of orthopaedics and sports medicine · 2022Article
- [Application of medical biomaterials in prevention and treatment of tendon adhesion].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020Review
- Matrix regeneration proteins in the hypoxia-triggered exosomes of shoulder tenocytes and adipose-derived mesenchymal stem cells.Molecular and cellular biochemistry · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rotator cuff (RC) tendons could beinflicted in many ways with an eventual outcome of pain, weakness and disability, which represent a large burden on health care cost. However, optimal healing, either conservatively or with surgical intervention, remains an issue that needs further investigation. Disorders of the RC tendons may result from external factors like trauma, or internal factors through physiologic and metabolic derangement. Most RC tendon disorders may be asymptomatic and may result from an over-activity of the inflicted shoulder and its tendons. Such tendon disorders are poorly diagnosed since patients do not seek medical attention until pain or weakness ensue. Immunological and biochemical events in RC disorders due to mechanical intolerance have not been investigated. Generally, the mechanical load drives normal physiological properties of the tendon. But, mechanical overload/burden exerts stress on tenocytes, and disrupts the tendon microenvironment by triggering a multitude of signaling pathways leading to extracellular matrix remodeling, disorganization, alteration in collagen composition and apoptosis. These events result in weak tendon which is highly susceptible to rupture or tear. In this article, we critically reviewed the intrinsic signaling pathways that are excessively triggered by continuous mechanical load and the counteracting physiological responses and associated derangements. The elucidation of the molecular events underlying mechanical stress-induced symptomatic/asymptomatic tendinopathy could provide information on potential target sites for translational application in the management of rotator cuff disorders.
Indexed as
Identifiers
29118899PMC5666046What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.