ArticleAnnals of thoracic medicine
Characteristics and predictors of mortality of patients with hematologic malignancies requiring invasive mechanical ventilation.
Article in Annals of thoracic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 26 citations in OpenAlex.
- Critically ill adult patients with acute leukemia: a systematic review and meta-analysis.Annals of intensive care · 2025Article
- [Chinese expert consensus on diagnosis, treatment and management of critically ill patients in hematology intensive care unit (2025)].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2025Article
- [Strengthen the construction of hematological intensive care unit to comprehensively improve the prognosis of patients with hematological critical illnesses].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2025Article
- Changes in respiratory infection trends during the COVID-19 pandemic in patients with haematologic malignancy.BMC pulmonary medicine · 2024Article
- Action Mechanism of Metformin and Its Application in Hematological Malignancy Treatments: A Review.Biomolecules · 2023Review
- Code status transitions in patients with high-risk acute myeloid leukemia.Blood advances · 2022Article
- The Predictive Role of Modified Early Warning Score in 174 Hematological Patients at the Point of Transfer to the Intensive Care Unit.Journal of clinical medicine · 2021Article
- Management strategy for hematological malignancy patients with acute respiratory failure.European journal of medical research · 2021Review
- Epidemiology, Clinical Characteristics, and Prognostic Factors in Critically Ill Patients with Hematolymphoid Malignancy.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Hematological malignancies in Polish population: what are the predictors of outcome in patients admitted to Intensive Care Unit?Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Extracorporeal membrane oxygenation inRespiratory medicine case reports · 2020Article
- Survival of mechanically ventilated patients admitted to intensive care units. Results from a tertiary care center between 2016-2018.Saudi medical journal · 2019Article
- Outcomes of Patients with Hematological Malignancies Admitted to the Intensive Care Unit at a Tertiary Care Center in Saudi Arabia.Saudi journal of medicine & medical sciencesArticle
- Outcome of Cancer Patients with an Unplanned Intensive Care Unit Admission: Predictors of Mortality and Long-term Survival.Saudi journal of medicine & medical sciencesArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleAcute respiratory failure (ARF) may complicate the course of hematologic malignancies (HMs). Our objective was to study the characteristics, outcomes and predictors of mortality of patients with HMs who required intubation for ARF.
methodsThis retrospective cohort study evaluated all patients with HMs who were admitted to the Intensive Care Unit (ICU) of King Abdul-Aziz Medical City-Riyadh between 2008 and 2013 and required invasive mechanical ventilation. We noted their baseline characteristics, treatments and different outcomes. Multivariable logistic regression analysis was performed to evaluate predictors of hospital mortality.
resultsDuring the 6-year period, 190 patients with HMs were admitted to the ICU and 122 (64.2%) required intubation for ARF. These patients had mean age of 57.2 ± 19.3 years and Acute Physiology and Chronic Health Evaluation II score of 28.0 ± 7.8 and were predominantly males (63.4%). Lymphoma (44.3%) and acute leukemia (38.5%) were the most common hematologic malignancy. Noninvasive ventilation (NIV) was tried in 22 patients (18.0%) but failed. The code status was changed to "Do-Not-Resuscitate" for 39 patients (32.0%) during ICU stay. Hospital mortality was 70.5% and most deaths (81.4%) occurred in the ICU. The mortality of patients with "Do-Not-Resuscitate" status was 97.4%. On multivariable logistic regression analysis, male gender (odds ratio (OR), 6.74; 95% confidence interval (CI), 2.24-20.30), septic shock (OR, 6.61; 95% CI, 1.93-22.66) were independent mortality predictors. Remission status, non-NIV failure and chemotherapy during ICU stay were not associated with mortality.
conclusionsPatients with HMs requiring intubation had high mortality (70.5%). Male gender and presence of septic shock were independent predictors of mortality.
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