ArticleScientific reports2017
Serology reflects a decline in the prevalence of trachoma in two regions of The Gambia.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Community-level chlamydial serology for assessing trachoma elimination in trachoma-endemic Niger.PLoS neglected tropical diseases · 2019Trial
- Data Resource Profile: Global Trachoma Serology Data Repository.International journal of epidemiology · 2025Article
- The Gambia Trachomatous Trichiasis Surveys: Results from Five Evaluation Units Confirm Attainment of Trachoma Elimination Thresholds.Ophthalmic epidemiology · 2024Article
- Prevalence of Trachoma following Implementation of the SAFE Strategy in Three Local Government Areas of Taraba State, North Eastern Nigeria.Ophthalmic epidemiology · 2023Article
- Prevalence of blindness and distance vision impairment in the Gambia across three decades of eye health programming.The British journal of ophthalmology · 2023Article
- Validation of immunoassays for the Chlamydia trachomatis antigen Pgp3 using a chimeric monoclonal antibody.Scientific reports · 2023Article
- A national survey integrating clinical, laboratory, and WASH data to determine the typology of trachoma in Nauru.PLoS neglected tropical diseases · 2022Article
- Predicting future community-level ocular Chlamydia trachomatis infection prevalence using serological, clinical, molecular, and geospatial data.PLoS neglected tropical diseases · 2022Article
- Surveillance for peri-elimination trachoma recrudescence: Exploratory studies in Ghana.PLoS neglected tropical diseases · 2021Article
- Lessons learned for surveillance strategies for trachoma elimination as a public health problem, from the evaluation of approaches utilised by Guinea worm and onchocerciasis programmes: A literature review.PLoS neglected tropical diseases · 2021Review
- Force-of-infection of Taenia solium porcine cysticercosis: a modelling analysis to assess global incidence and prevalence trends.Scientific reports · 2020Article
- The simplified trachoma grading system, amended.Bulletin of the World Health Organization · 2020Article
- The use of serology for trachoma surveillance: Current status and priorities for future investigation.PLoS neglected tropical diseases · 2020Review
- Household Survey of Trachoma among Children Living in Pernambuco, Brazil.Pathogens (Basel, Switzerland) · 2019Article
- Pgp3 seroprevalence and associations with active trachoma and ocular Chlamydia trachomatis infection in Malawi: cross-sectional surveys in six evaluation units.PLoS neglected tropical diseases · 2019Article
- Understanding the spatial distribution of trichiasis and its association with trachomatous inflammation-follicular.BMC infectious diseases · 2019Article
- How much trachomatous trichiasis is there? A guide to calculating district-level estimates.Community eye health · 2019Article
- Insights from mathematical modelling and quantitative analysis on the proposed 2030 goals for trachoma.Gates open research · 2019Article
- The utility of serology for elimination surveillance of trachoma.Nature communications · 2018Article
- Prevalence of trachoma in the Republic of Chad: results of 41 population-based surveys.Ophthalmic epidemiology · 2018Article
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Authors and funding
13 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trachoma is caused by Chlamydia trachomatis (Ct). It is targeted for global elimination as a public health problem. In 2014, a population-based cross-sectional study was performed in two previously trachoma-endemic areas of The Gambia. Participants of all ages from Lower River Region (LRR) (N = 1028) and Upper River Region (URR) (N = 840) underwent examination for trachoma and had blood collected for detection of antibodies against the Ct antigen Pgp3, by ELISA. Overall, 30 (1.6%) individuals had active trachoma; the prevalence in children aged 1-9 years was 3.4% (25/742) with no statistically significant difference in prevalence between the regions. There was a significant difference in overall seroprevalence by region: 26.2% in LRR and 17.1% in URR (p < 0.0001). In children 1-9 years old, seroprevalence was 4.4% in LRR and 3.9% in URR. Reversible catalytic models using information on age-specific seroprevalence demonstrated a decrease in the transmission of Ct infection in both regions, possibly reflecting the impact of improved access to water, health and sanitation as well as mass drug administration campaigns. Serological testing for antibodies to Ct antigens is potentially useful for trachoma programmes, but consideration should be given to the co-endemicity of sexually transmitted Ct infections.
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