ArticleScientific reports2017
Melatonin promotes triacylglycerol accumulation via MT2 receptor during differentiation in bovine intramuscular preadipocytes.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Melatonin Enhances Muscle Development and Suppresses Fat Deposition in Cashmere Goats by Implicating Gut Microbiota and Ameliorating Systemic Antioxidant Status.Antioxidants (Basel, Switzerland) · 2025Article
- Exploring the regulatory mechanisms of differentially expressed circRNAs during bovine intramuscular adipogenic differentiation.BMC genomics · 2025Article
- Identification of Gut Microbiome Signatures Associated with Serotonin Pathway in Tryptophan Metabolism of Patients Undergoing Hemodialysis.International journal of molecular sciences · 2025Article
- Daily Lipolysis Gene Expression in Male Rat Mesenteric Adipose Tissue: Obesity and Melatonin Effects.International journal of molecular sciences · 2025Article
- Impact of an extended light regimen imposed during nursery period on the performance and lipid metabolism of weanling pigs.Animal bioscience · 2025Article
- Melatonin in animal husbandry: functions and applications.Frontiers in veterinary science · 2024Review
- RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway.Journal of animal science and biotechnology · 2023Article
- A genome-wide landscape of mRNAs, lncRNAs, circRNAs and miRNAs during intramuscular adipogenesis in cattle.BMC genomics · 2022Article
- Effects of Implanting Exogenous Melatonin 40 Days before Lambing on Milk and Colostrum Quality.Animals : an open access journal from MDPI · 2022Article
- The role of melatonin in the molecular mechanisms underlying metaflammation and infections in obesity: A narrative review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- Mechanisms of Melatonin in Obesity: A Review.International journal of molecular sciences · 2021Review
- Implanting melatonin at lambing enhances lamb growth and maintains high fat content in milk.Veterinary research communications · 2021Article
- Metabolic flexibility during sleep.Scientific reports · 2021Article
- Metabolic responses to polychromatic LED and OLED light at night.Scientific reports · 2021Article
- Elucidating the Regulatory Role of Melatonin in Brown, White, and Beige Adipocytes.Advances in nutrition (Bethesda, Md.) · 2020Review
- Biological effects of melatonin on human adipose‑derived mesenchymal stem cells.International journal of molecular medicine · 2019Article
- Melatonin Modulation of Radiation and Chemotherapeutics-induced Changes on Differentiation of Breast Fibroblasts.International journal of molecular sciences · 2019Article
- Higher melatonin in the follicle fluid and MT2 expression in the granulosa cells contribute to the OHSS occurrence.Reproductive biology and endocrinology : RB&E · 2019Article
- Intramuscular adipocytes: a buried adipose tissue depot deserving more exploration.Journal of lipid research · 2019Article
- Melatonin reduces intramuscular fat deposition by promoting lipolysis and increasing mitochondrial function.Journal of lipid research · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melatonin (N-acetyl-5-methoxytryptamine) is a derivative of tryptophan which is produced and secreted mainly by the pineal gland and regulates a variety of important central and peripheral actions. To examine the potential effects of melatonin on the proliferation and differentiation of bovine intramuscular preadipocytes (BIPs), BIPs were incubated with different concentrations of melatonin. Melatonin supplementation at 1 mM significantly increased peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer-binding protein (C/EBP) β, and C/EBPα expression and promoted the differentiation of BIPs into adipocytes with large lipid droplets and high cellular triacylglycerol (TAG) levels. Melatonin also significantly enhanced lipolysis and up-regulated the expression of lipolytic genes and proteins, including hormone sensitive lipase (HSL), adipocyte triglyceride lipase (ATGL), and perilipin 1 (PLIN1). Moreover, melatonin reduced intracellular reactive oxygen species (ROS) levels by increasing the expression levels and activities of superoxide dismutase 1 (SOD1) and glutathione peroxidase 4 (GPX4). Finally, the positive effects of melatonin on adipogenesis, lipolysis, and redox status were reversed by treatment with luzindole, anantagonist of nonspecific melatonin receptors 1 (MT1) and 2 (MT2), and 4-phenyl-2-propionamidotetraline (4P-PDOT), a selective MT2 antagonist. These results reveal that melatonin promotes TAG accumulation via MT2 receptor during differentiation in BIPs.
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