ArticleScientific reports2017
Novel serotonin transporter regulators: Natural aristolane- and nardosinane- types of sesquiterpenoids from Nardostachys chinensis Batal.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 35 citations in OpenAlex.
- Chemical analysis, antioxidant and antimicrobial activities ofFrontiers in nutrition · 2026Article
- Natural Occurring Terpene Cyclic Anhydrides: Biosynthetic Origin and Biological Activities.Biomolecules · 2024Review
- Research Progress on Sesquiterpene Compounds from Artabotrys Plants of Annonaceae.Molecules (Basel, Switzerland) · 2024Review
- Degradation Profiling of Nardosinone at High Temperature and in Simulated Gastric and Intestinal Fluids.Molecules (Basel, Switzerland) · 2023Article
- Structures, Occurrences and Biosynthesis of 11,12,13-Tri-Plants (Basel, Switzerland) · 2022Review
- Plant Species of Sub-Family Valerianaceae-A Review on Its Effect on the Central Nervous System.Plants (Basel, Switzerland) · 2021Review
- Chemical Analysis of the Ingredients of 20% Aqueous Ethanol Extract ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Aristolane-type Sesquiterpenoids from Nardostachys chinensis and Revised Structure of Aristolanhydride.Natural products and bioprospecting · 2019Article
- Isolation of Novel Sesquiterpeniods and Anti-neuroinflammatory Metabolites fromMolecules (Basel, Switzerland) · 2018Article
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Authors and funding
13 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Serotonin transporter (SERT) is a classic target of drug discovery for neuropsychiatric and digestive disorders, and against those disorders, plants of Nardostachys genus have been valued for centuries in the systems of Traditional Chinese Medicine, Ayurvedic and Unani. Herein, chemical investigation on the roots and rhizomes of Nardostachys chinensis Batal. led to the isolation of forty sesquiterpenoids including six new aristolane-type sesquiterpenoids and six new nardosinane-type sesquiterprenoids. Their structures were elucidated by extensive spectroscopic methods, combined with analyses of circular dichroism and single-crystal X-ray diffraction data. To explore natural product scaffolds with SERT regulating activity, a high-content assay for measurement of SERT function in vitro was conducted to evaluate the SERT regulating properties of these isolates. In conclusion, eleven compounds could be potential natural product scaffolds for developing drug candidates targeting SERT. Among which, kanshone C of aristolane-type sesquiterpenoid inhibited SERT most strongly, while desoxo-nachinol A of nardosinane-type sesquiterpenoid instead enhanced SERT potently.
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