ArticleMedical science monitor : international medical journal of experimental and clinical research2017
Association of Immune Factors with Drug-Resistant Tuberculosis: A Case-Control Study.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Application of Clinical-Radiomics Fusion Model in Predicting Drug Resistance of Cavitary Pulmonary Tuberculosis.Infection and drug resistance · 2026Article
- Risk factors for multidrug-resistant tuberculosis: a predictive model study.Frontiers in medicine · 2024Article
- Clinical and Computed Tomography Features Associated with Multidrug-Resistant Pulmonary Tuberculosis: A Retrospective Study in China.Infection and drug resistance · 2023Article
- Risk for multidrug-resistant tuberculosis in patients treated with anti-tumor necrosis factor agents.Frontiers in medicine · 2023Article
- Evolution of Drug-ResistantFrontiers in microbiology · 2021Review
- Article
- Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda.Journal of tropical medicine · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Presently, studies of factors associated with drug-resistant tuberculosis (TB) focus on patients' socio-demographic characteristics and living habits, to the exclusion of biochemical indicators, especially immune factors. This study was carried out to determine whether immune factors are associated with drug-resistant TB. MATERIAL AND METHODS A total of 227 drug-resistant pulmonary TB patients and 225 drug-susceptible pulmonary TB patients were enrolled in this study. Information on socio-demographic characteristics and biochemical indicators were obtained through their clinical records. Non-conditional logistic regression was used to analyze the association of these indicators with drug-resistant TB. RESULTS There were significant differences in re-treatment, marital status, alanine aminotransferase (ALT), blood uric acid (BUA), carcino-embryonic antigen (CEA), T-spot, and CD3 and CD4 counts between the 2 groups. In multivariable analysis, re-treatment [Odds Ratio (OR)=5.290, 95% Confidence Interval [CI]=2.652-10.551); CD3 (OR=1.034, 95% CI=1.001-1.068); CD4 (OR=1.035, 95% CI =1.001-1.070) and IgM (OR=1.845, 95% CI=1.153-2.952) were associated with drug-resistant TB. CONCLUSIONS These results suggest the need for greater attention to re-treatment cases and immune function when treating drug-resistant TB.
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