Evidence map›Paper›PMID 29118214›Full record

ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Central Network Dynamics Regulating Visceral and Humoral Functions.

Rita J Valentino, Patrice Guyenet, Xun Helen Hou, Melissa Herman

Abstract readReview
In one paragraph

Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Peripheral catecholamine systems: an evolutionary perspective.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rita J ValentinoChildren's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104, valentinorj@nida.nih.gov.ORCID 0000-0001-6839-6628
Patrice GuyenetUniversity of Virginia, Charlottesville, Virginia 22908.ORCID 0000-0003-1739-2306
Xun Helen HouHarvard University, Boston, Massachusetts 02115, and.
Melissa HermanUniversity of North Carolina, Chapel Hill, North Carolina 27599.

Funding

Retrotrapezoid nucleus and central chemoreceptionR01HL074011 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GUYENET, PATRICE G. · 2003 to 2018
$6.6M
Organization of Central Sympathic PathwaysR01HL028785 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI STORNETTA, RUTH L · 1985 to 2020
$5.0M
ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYSR37HL028785 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GUYENET, PATRICE G. · 1999 to 2008
$3.0M
Alcohol-induced plasticity within CRF2 microcircuits in distinct amygdala nucleiR00AA023002 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HERMAN, MELISSA A · 2017 to 2019
$732k
ProjectP20DK103086 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MATHAI, JOHN · 2014 to 2015
$694k
Central processing of bladder informationR56DK102367 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI VALENTINO, RITA · 2014 to 2015
$504k
Optogenetic characterization of Corticotropin-releasing factor neurons of Barrington's NucleusR21AG052780 · NIA · GEORGETOWN UNIVERSITY · PI VICINI, STEFANO · 2016 to 2017
$459k
Alcohol-induced plasticity within CRF2 microcircuits in distinct amygdala nucleiK99AA023002 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HERMAN, MELISSA A · 2015 to 2016
$284k
NHLBI NIH HHS R01 HL028785NHLBI NIH HHS R01 HL074011NHLBI NIH HHS R37 HL028785NIAAA NIH HHS K99 AA023002NIAAA NIH HHS R00 AA023002NIA NIH HHS R21 AG052780NIDDK NIH HHS P20 DK103086NIDDK NIH HHS R56 DK102367
6 · The paper itself

Abstract

The brain processes information from the periphery and regulates visceral and immune activity to maintain internal homeostasis, optimally respond to a dynamic external environment, and integrate these functions with ongoing behavior. In addition to its relevance for survival, this integration underlies pathology as evidenced by diseases exhibiting comorbid visceral and psychiatric symptoms. Advances in neuroanatomical mapping, genetically specific neuronal manipulation, and neural network recording are overcoming the challenges of dissecting complex circuits that underlie this integration and deciphering their function. Here we focus on reciprocal communication between the brain and urological, gastrointestinal, and immune systems. These studies are revealing how autonomic activity becomes integrated into behavior as part of a social strategy, how the brain regulates innate immunity in response to stress, and how drugs impact emotion and gastrointestinal function. These examples highlight the power of the functional organization of circuits at the interface of the brain and periphery.

Indexed as

AnimalsCentral Nervous SystemGastrointestinal TractHomeostasisHumansImmunity, HumoralNerve Netautonomicgastrointestinalimmunemedullamicturitionpons

Identifiers

PMID29118214
PMCPMC5678017

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.