Evidence map›Paper›PMID 29118210›Full record

ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Illuminating Neural Circuits: From Molecules to MRI.

Jin Hyung Lee, Anatol C Kreitzer, Annabelle C Singer, Nicholas D Schiff

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Optogenetic fMRI for Brain-Wide Circuit Analysis of Sensory Processing.International journal of molecular sciences · 2022
    Pooled it
  2. Frontostriatal regulation of brain circuits contributes to flexible decision making.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Developing Precision Invasive Neuromodulation for Psychiatry.The Journal of neuropsychiatry and clinical neurosciences · 2021
    Article
  7. Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Jin Hyung LeeStanford University, Stanford, California 94305, ljinhy@stanford.edu.
Anatol C KreitzerGladstone Institute, San Francisco, California 94158.
Annabelle C SingerGeorgia Institute of Technologyand Emory School of Medicine, Atlanta, Georgia 30332, and.
Nicholas D SchiffWeill Medical College of Cornell University, New York, New York 10065.
Cornell University · USGeorgia Institute of Technology · USGladstone Institutes · USStanford University · US

Funding

Neuron- and Circuit-Specific Mechanisms and Adaptations Regulating Striatal FunctR01NS064984 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI KREITZER, ANATOL · 2009 to 2022
$5.1M
Deconstructing Arousal Regulation Circuits for Optimal DBS Therapy DesignR01NS087159 · NINDS · STANFORD UNIVERSITY · PI LEE, JIN HYUNG · 2014 to 2018
$1.9M
Direct Visualization of Cell-Type Specific AD Networks for Drug DevelopmentRF1AG047666 · NIA · STANFORD UNIVERSITY · PI LEE, JIN HYUNG · 2014 to 2014
$1.8M
NIA NIH HHS RF1 AG047666NINDS NIH HHS R01 NS064984NINDS NIH HHS R01 NS087159
6 · The paper itself

Abstract

Neurological disease drives symptoms through pathological changes to circuit functions. Therefore, understanding circuit mechanisms that drive behavioral dysfunction is of critical importance for quantitative diagnosis and systematic treatment of neurological disease. Here, we describe key technologies that enable measurement and manipulation of neural activity and neural circuits. Applying these approaches led to the discovery of circuit mechanisms underlying pathological motor behavior, arousal regulation, and protein accumulation. Finally, we discuss how optogenetic functional magnetic resonance imaging reveals global scale circuit mechanisms, and how circuit manipulations could lead to new treatments of neurological diseases.

Indexed as

AnimalsBrainHumansMagnetic Resonance ImagingMolecular ImagingNervous System DiseasesNeural PathwaysOptogeneticsAlzheimer's diseasearousalbasal gangliagamma frequencyofMRIoptogenetics

Identifiers

PMID29118210
PMCPMC5678014
OpenAlexW2785043665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.