Evidence map›Paper›PMID 29118207›Full record

ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Emerging Mechanisms Underlying Dynamics of GABAergic Synapses.

Arianna Maffei, Cécile Charrier, Maddalena Delma Caiati, Andrea Barberis, Vivek Mahadevan, Melanie A Woodin, Shiva K Tyagarajan

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Cells · 2024
    Review
  7. Article
  8. Article
  9. Activation of TrkB in Parvalbumin interneurons is required for the promotion of reversal learning in spatial and fear memory by antidepressants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  10. Article
  11. Review
  12. Axonal CB1 Receptors Mediate Inhibitory Bouton Formation via cAMP Increase and PKA.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  13. Review
  14. The Logic of Developing Neocortical Circuits in Health and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Review
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 5 countries.

Arianna MaffeiDepartment of Neurobiology and Behavior, State University of New York, Stony Brook, New York 11794-5230.ORCID 0000-0001-6755-8904
Cécile CharrierInstitut de Biologie de l'Ecole Normale Supérieure, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Ecole Normale Supérieure, PSL Research University, F-75005 Paris, France.
Maddalena Delma CaiatiDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138.
Andrea BarberisFondazione Istituto Italiano di Tecnologia, 16163 Genova GE, Italy.ORCID 0000-0002-5054-6517
Vivek MahadevanNational Institute of Child Health and Human Development, Bethesda, Maryland 20892.ORCID 0000-0002-0805-827X
Melanie A WoodinDepartment of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada, and.ORCID 0000-0003-2984-8630
Shiva K TyagarajanInstitute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland tyagarajan@pharma.uzh.ch.ORCID 0000-0003-0074-1805
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USHarvard University · USItalian Institute of Technology · ITState University of New York · USUniversité Paris Sciences et Lettres · FRUniversity of Toronto · CAUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inhibitory circuits are diverse, yet with a poorly understood cell biology. Functional characterization of distinct inhibitory neuron subtypes has not been sufficient to explain how GABAergic neurotransmission sculpts principal cell activity in a relevant fashion. Our Mini-Symposium brings together several emerging mechanisms that modulate GABAergic neurotransmission dynamically from either the presynaptic or the postsynaptic site. The first two talks discuss novel developmental and neuronal subtype-specific contributions to the excitatory/inhibitory balance and circuit maturation. The next three talks examine how interactions between cellular pathways, lateral diffusion of proteins between synapses, and chloride transporter function at excitatory and inhibitory synapses and facilitate inhibitory synapse adaptations. Finally, we address functional differences within GABAergic interneurons to highlight the importance of diverse, flexible, and versatile inputs that shape network function. Together, the selection of topics demonstrates how developmental and activity-dependent mechanisms coordinate inhibition in relation to the excitatory inputs and vice versa.

Indexed as

Animalsgamma-Aminobutyric AcidHumansNerve NetNeuronal PlasticitySynapsesSynaptic Transmissiongamma-Aminobutyric AcidCaMKIIagephyrnhomeostatic plasticityinterneuronsKCC2postsynaptic density

Identifiers

PMID29118207
PMCPMC5678011
OpenAlexW2783611170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.