ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Social Origins of Developmental Risk for Mental and Physical Illness.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Sensitive periods in development and risk for psychiatric disorders and related endpoints: a systematic review of child maltreatment findings.The lancet. Psychiatry · 2022Pooled it
- C-low threshold mechanoreceptors: a novel target for health-tech in an increasingly touch-deprived world.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- The influence of early childhood education and care on the relation between early-life social adversity and children's mental health in the environmental influences for Child Health Outcomes Program.Development and psychopathology · 2025Observational
- The dynamic relationship of brain-derived neurotrophic factor and oxytocin: Introducing the concept of neurosocial plasticity.Neuroprotection (Chichester, England) · 2025Review
- Microglia Morphology in the Developing Primate Amygdala and Effects of Early Life Stress.eNeuro · 2025Article
- Impact of COVID-19 School Closures on White Matter Plasticity in the Reading Network.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Greater Frontoparietal Connectivity During Task Engagement Among Toddlers With Parent-Reported Inattention.Developmental psychobiology · 2024Article
- Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder.Communications biology · 2024Article
- Synaptic pruning during adolescence shapes adult social behavior in both males and females.Developmental psychobiology · 2024Article
- Early life stress shifts critical periods and causes precocious visual cortex development.PloS one · 2024Article
- Legacies of salient environmental experiences-insights from chemosensation.Chemical senses · 2024Article
- Early-Life Stress Impairs Perception and Neural Encoding of Rapid Signals in the Auditory Pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Immature neurons in the primate amygdala: changes with early development and disrupted early environment.bioRxiv : the preprint server for biology · 2023Article
- Psychosis spectrum illnesses as disorders of prefrontal critical period plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Association between childhood trauma and mental health disorders in adolescents during the second pandemic wave of COVID-19, Chiclayo-Peru.Frontiers in psychiatry · 2023Article
- How to Mitigate Risk of Premature Cardiovascular Disease Among Children and Adolescents with Mental Health Conditions.Current atherosclerosis reports · 2022Review
- Sensitive period-regulating genetic pathways and exposure to adversity shape risk for depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Vulnerability and resilience in children during the COVID-19 pandemic.European child & adolescent psychiatry · 2022Article
- Change of pace: How developmental tempo varies to accommodate failed provision of early needs.Neuroscience and biobehavioral reviews · 2021Review
- Does Psychedelic Therapy Have a Transdiagnostic Action and Prophylactic Potential?Frontiers in psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Adversity in early childhood exerts an enduring impact on mental and physical health, academic achievement, lifetime productivity, and the probability of interfacing with the criminal justice system. More science is needed to understand how the brain is affected by early life stress (ELS), which produces excessive activation of stress response systems broadly throughout the child's body (toxic stress). Our research examines the importance of sex, timing and type of stress exposure, and critical periods for intervention in various brain systems across species. Neglect (the absence of sensitive and responsive caregiving) or disrupted interaction with offspring induces robust, lasting consequences in mice, monkeys, and humans. Complementary assessment of internalizing disorders and brain imaging in children suggests that early adversity can interfere with white matter development in key brain regions, which may increase risk for emotional difficulties in the long term. Neural circuits that are most plastic during ELS exposure in monkeys sustain the greatest change in gene expression, offering a mechanism whereby stress timing might lead to markedly different long-term behaviors. Rodent models reveal that disrupted maternal-infant interactions yield metabolic and behavioral outcomes often differing by sex. Moreover, ELS may further accelerate or delay critical periods of development, which reflect GABA circuit maturation, BDNF, and circadian
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.