Evidence map›Paper›PMID 29118176›Full record

ArticleJournal of clinical microbiology2018

Highly Sensitive Detection of Isoniazid Heteroresistance in Mycobacterium tuberculosis by DeepMelt Assay.

Bin Liang, Yaoju Tan, Zi Li, Xueshan Tian, Chen Du, Hui Li, Guoli Li, Xiangyang Yao, Zhongan Wang, Ye Xu and 1 more

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Journal of clinical microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  6. Identification and quantification ofJournal of clinical microbiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Bin Liang *Engineering Research Centre of Molecular Diagnostics, Ministry of Education, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
Yaoju Tan *Department of Clinical Laboratory, Guangzhou Chest Hospital, Guangzhou, China.
Zi LiEngineering Research Centre of Molecular Diagnostics, Ministry of Education, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
Xueshan TianEngineering Research Centre of Molecular Diagnostics, Ministry of Education, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
Chen DuEngineering Research Centre of Molecular Diagnostics, Ministry of Education, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.
Hui LiTuberculosis Reference Laboratory, Henan Provincial Center for Disease Control and Prevention, Zhengzhou, Henan, China.
Guoli LiInstitute for Tuberculosis Research, the 309th Hospital of Chinese PLA, Beijing, China.
Xiangyang YaoFirst Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
Zhongan WangSchool of Life Sciences, Xiamen University, Xiamen, Fujian, China.
Ye XuEngineering Research Centre of Molecular Diagnostics, Ministry of Education, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China xuye@xmu.edu.cn qgli@xmu.edu.cn.
Qingge LiEngineering Research Centre of Molecular Diagnostics, Ministry of Education, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China xuye@xmu.edu.cn qgli@xmu.edu.cn.
Xiamen University · CNFirst Affiliated Hospital of Xiamen University · CNGuangzhou Chest Hospital · CNHenan Provincial Center for Disease Control and Prevention · CNThe 309th Hospital of Chinese People's Liberation Army · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Detection of heteroresistance of

Indexed as

Molecular Diagnostic TechniquesAntitubercular AgentsBacterial ProteinsDNA, BacterialDrug Resistance, BacterialHumansIsoniazidMicrobial Sensitivity TestsMycobacterium tuberculosisOxidoreductasesPolymerase Chain ReactionSensitivity and SpecificitySequence Analysis, DNASputumTuberculosis, Multidrug-ResistantAntitubercular AgentsBacterial ProteinsDNA, BacterialInhA protein, MycobacteriumIsoniazidOxidoreductasesclampingheteroresistanceisoniazid-resistant tuberculosismelting curve analysisMycobacterium tuberculosis

Identifiers

PMID29118176
PMCPMC5786724
OpenAlexW2767666085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.