ArticleJournal of clinical microbiology2018
Total Laboratory Automation and Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry Improve Turnaround Times in the Clinical Microbiology Laboratory: a Retrospective Analysis.
Article in Journal of clinical microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Total Laboratory Automation for Microbiology Activities: An HTA Analysis in an Italian Laboratory Setting.ClinicoEconomics and outcomes research : CEOR · 2026Article
- High Fluorescent Cells on Automated Body Fluid Analysis as Discriminator for Malignant Cell Detection.South Asian journal of cancer · 2025Article
- Diagnostic Approaches forMicroorganisms · 2025Review
- The Impact of Laboratory Automation on the Time to Urine Microbiological Results: A Five-Year Retrospective Study.Diagnostics (Basel, Switzerland) · 2024Article
- Conversion of a classical microbiology laboratory to a total automation laboratory enhanced by the application of lean principles.Microbiology spectrum · 2024Article
- Application of MALDI-TOF MS for enumerating bacterial constituents of defined consortia.Applied microbiology and biotechnology · 2023Article
- Diagnostic test accuracy of an automated device for the MALDI target preparation for microbial identification.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Article
- Laboratory automation, informatics, and artificial intelligence: current and future perspectives in clinical microbiology.Frontiers in cellular and infection microbiology · 2023Article
- Total Laboratory Automation for Rapid Detection and Identification of Microorganisms and Their Antimicrobial Resistance Profiles.Frontiers in cellular and infection microbiology · 2022Review
- The Need for Dedicated Microbiology Leadership in the Clinical Microbiology Laboratory.Journal of clinical microbiology · 2021Article
- Benefits Derived from Full Laboratory Automation in Microbiology: a Tale of Four Laboratories.Journal of clinical microbiology · 2021Article
- Evaluation of three sample preparation methods for the identification of clinical strains by using two MALDI-TOF MS systems.Journal of mass spectrometry : JMS · 2021Article
- Total Laboratory Automation and Three Shifts Reduce Turnaround Time of Cerebrospinal Fluid Culture Results in the Chinese Clinical Microbiology Laboratory.Frontiers in cellular and infection microbiology · 2021Article
- Clinical Performance of BD Kiestra InoqulA Automated System in a Chinese Tertiary Hospital.Infection and drug resistance · 2020Article
- Reducing the time between inoculation and first-read of urine cultures using total lab automation significantly reduces turn-around-time of positive culture results with minimal loss of first-read sensitivity.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
- Evaluation of matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS) for the Identification of Group B Streptococcus.BMC research notes · 2019Article
- Investigating Antifungal Susceptibility inFrontiers in cellular and infection microbiology · 2019Review
- Laboratory automation reduces time to report of positive blood cultures and improves management of patients with bloodstream infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Impact of total laboratory automation on workflow and specimen processing time for culture of urine specimens.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Blood Culture Results Reporting: How Fast Is Your Laboratory and Is Faster Better?Journal of clinical microbiology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Technological advances have changed the practice of clinical microbiology. We implemented Bruker matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and BD Kiestra total laboratory automation (TLA) 4 and 3 years ago, respectively. To assess the impact of these new technologies, we compared turnaround times (TATs) for positive and negative urine cultures before and after implementation. In comparison I, TATs for 61,157 urine cultures were extracted for two periods corresponding to pre-TLA and post-TLA, both using MALDI-TOF MS for organism identification. In comparison II, time to organism identification (ID) and antimicrobial susceptibility (AST) reports were calculated for 5,402 positive culture reports representing four different periods: (i) manual plating and conventional biochemical identification (CONV), (ii) manual plating and MALDI-TOF MS identification (MALDI), (iii) MALDI-TOF MS identification and early phase implementation of TLA (TLA1), and (iv) MALDI-TOF MS identification and late phase implementation of TLA (TLA2). By the comparison I results, median pre- and post-TLA TATs to organism IDs (18.5 to 16.9 h), AST results (41.8 to 40.8 h), and preliminary results for negative cultures (17.7 to 13.6 h), including interquartile ranges for all comparisons, were significantly decreased post-TLA (
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