Evidence map›Paper›PMID 29118162›Full record

ArticleCancer prevention research (Philadelphia, Pa.)2018

Does Mutated

Photini F S Rice, Kevin G Ehrichs, Mykella S Jones, Hwudarw Chen, Chiu-Hsieh Hsu, Edward R Abril, Raymond B Nagle, David G Besselsen, Jennifer K Barton, Natalia A Ignatenko

Abstract read
In one paragraph

Article in Cancer prevention research (Philadelphia, Pa.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Structural modifications and kinetic effects ofFrontiers in molecular biosciences · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Photini F S RiceDepartment of Biomedical Engineering, University of Arizona, Tucson, Arizona.
Kevin G EhrichsDepartment of Biomedical Engineering, University of Arizona, Tucson, Arizona.
Mykella S JonesDepartment of Biomedical Engineering, University of Arizona, Tucson, Arizona.
Hwudarw ChenUniversity of Arizona Cancer Center, University of Arizona, Tucson, Arizona.
Chiu-Hsieh HsuMel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona.
Edward R AbrilUniversity of Arizona Cancer Center, University of Arizona, Tucson, Arizona.
Raymond B NagleDepartment of Pathology, University of Arizona, Tucson, Arizona.
David G BesselsenUniversity Animal Care, University of Arizona, Tucson, Arizona.
Jennifer K BartonDepartment of Biomedical Engineering, University of Arizona, Tucson, Arizona.
Natalia A IgnatenkoUniversity of Arizona Cancer Center, University of Arizona, Tucson, Arizona. nai@email.arizona.edu.

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Teri L Bankhead · 1985 to 2026
$110.2M
Dual-Modality System for Imaging Colon Cancer in MiceR01CA109385 · NCI · UNIVERSITY OF ARIZONA · PI BARTON, JENNIFER KEHLET · 2004 to 2013
$3.1M
Role of Kallikrein 6 expression and secretion in colon cancerR01CA157595 · NCI · UNIVERSITY OF ARIZONA · PI IGNATENKO, NATALIA A · 2012 to 2016
$1.7M
NCI NIH HHS P30 CA023074NCI NIH HHS R01 CA109385NCI NIH HHS R01 CA157595
6 · The paper itself

Abstract

The NSAID sulindac has been successfully used alone or in combination with other agents to suppress colon tumorigenesis in patients with genetic predisposition and also showed its efficacy in prevention of sporadic colon adenomas. At the same time, some experimental and clinical reports suggest that a mutant

Indexed as

MutationAnimalsAntineoplastic AgentsAzoxymethaneCarcinogensCell Transformation, NeoplasticColonic NeoplasmsMiceMice, Inbred C57BLProto-Oncogene Proteins p21(ras)SulindacAntineoplastic AgentsAzoxymethaneCarcinogensHras protein, mouseProto-Oncogene Proteins p21(ras)Sulindac

Identifiers

PMID29118162
PMCPMC7733710

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.