Evidence map›Paper›PMID 29118161›Full record

ArticleCancer prevention research (Philadelphia, Pa.)2018

Dietary Nutrient Intake, Ethnicity, and Epigenetic Silencing of Lung Cancer Genes Detected in Sputum in New Mexican Smokers.

Shuguang Leng, Maria A Picchi, Huining Kang, Guodong Wu, Piotr T Filipczak, Daniel E Juri, Xiequn Zhang, W James Gauderman, Frank D Gilliland, Steven A Belinsky

Open access · bronzeAbstract read
In one paragraph

Article in Cancer prevention research (Philadelphia, Pa.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Shuguang LengLung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico. sleng@LRRI.org sbelinsk@LRRI.org.
Maria A PicchiLung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico.
Huining KangDepartment of Internal Medicine and UNM Comprehensive Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
Guodong WuLung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico.
Piotr T FilipczakLung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico.
Daniel E JuriLung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico.
Xiequn ZhangLung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico.
W James GaudermanKeck School of Medicine, University of Southern California, Los Angeles, California.
Frank D GillilandKeck School of Medicine, University of Southern California, Los Angeles, California.
Steven A BelinskyLung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico. sleng@LRRI.org sbelinsk@LRRI.org.
University of Southern California · US

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI David V Conti · 2016 to 2026
$25.5M
Factors for Epigenetic Silencing of Lung Cancer GenesR01CA097356 · NCI · LOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE · PI BELINSKY, STEVEN A · 2004 to 2014
$6.3M
NCI NIH HHS P01 CA196569NCI NIH HHS P30 CA118100NCI NIH HHS R01 CA097356
6 · The paper itself

Abstract

Lung cancer gene methylation detected in sputum assesses field cancerization and predicts lung cancer incidence. Hispanic smokers have higher lung cancer susceptibility compared with non-Hispanic whites (NHW). We aimed to identify novel dietary nutrients affecting lung cancer gene methylation and determine the degree of ethnic disparity in methylation explained by diet. Dietary intakes of 139 nutrients were assessed using a validated Harvard food frequency questionnaire in 327 Hispanics and 1,502 NHWs from the Lovelace Smokers Cohort. Promoter methylation of 12 lung cancer genes was assessed in sputum DNA. A global association was identified between dietary intake and gene methylation (

Indexed as

Epigenesis, GeneticAdultAgedBiomarkers, TumorDietDNA MethylationEnergy IntakeEthnicityFemaleFollow-Up StudiesGene SilencingHumansLongitudinal StudiesLung NeoplasmsMaleMiddle AgedBiomarkers, TumorNutrients

Identifiers

PMID29118161
PMCPMC7531230
OpenAlexW2767679886

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.