Evidence map›Paper›PMID 29118127›Full record

ArticleJournal of virology2018

Peripheral Blood Biomarkers of Disease Outcome in a Monkey Model of Rift Valley Fever Encephalitis.

Elizabeth R Wonderlich, Amy L Caroline, Cynthia M McMillen, Aaron W Walters, Douglas S Reed, Simon M Barratt-Boyes, Amy L Hartman

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. In Vitro Evaluation of Bunyavirus T Cell Immunity.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  5. Review
  6. Article
  7. Laboratory Animal Models for Rift Valley Fever Virus Disease.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Elizabeth R WonderlichCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Amy L CarolineCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Cynthia M McMillenCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Aaron W WaltersCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Douglas S ReedCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Simon M Barratt-BoyesCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Amy L HartmanCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA hartman2@pitt.edu.ORCID http://orcid.org/0000-0002-0857-2973
University of Pittsburgh · US

Funding

Vervet Research Colony as a Biomedical ResourceP40OD010965 · OD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Matthew Jorgensen · 2012 to 2026
$14.6M
NIH HHS P40 OD010965
6 · The paper itself

Abstract

Rift Valley Fever (RVF) is an emerging arboviral disease of livestock and humans. Although the disease is caused by a mosquito-borne virus, humans are infected through contact with, or inhalation of, virus-laden particles from contaminated animal carcasses. Some individuals infected with RVF virus (RVFV) develop meningoencephalitis, resulting in morbidity and mortality. Little is known about the pathogenic mechanisms that lead to neurologic sequelae, and thus, animal models that represent human disease are needed. African green monkeys (AGM) exposed to aerosols containing RVFV develop a reproducibly lethal neurological disease that resembles human illness. To understand the disease process and identify biomarkers of lethality, two groups of 5 AGM were infected by inhalation with either a lethal or a sublethal dose of RVFV. Divergence between lethal and sublethal infections occurred as early as 2 days postinfection (dpi), at which point CD8

Indexed as

AnimalsAntibodies, ViralBiomarkersCaspase 3Chlorocebus aethiopsCytokinesDisease Models, AnimalFemaleGenes, MHC Class IIHumansLymphocyte ActivationMeningoencephalitisRift Valley FeverRift Valley fever virusT-LymphocytesVirionAntibodies, ViralBiomarkersCaspase 3CytokinesaerosolsAfrican green monkeybunyaviruscaspasescytokinesencephalitisRift Valley fever virusviral pathogenesis

Identifiers

PMID29118127
PMCPMC5774883
OpenAlexW2767434988

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.