ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Morphological Constraints on Cerebellar Granule Cell Combinatorial Diversity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- A computational model of the cerebellar granular layer calibrated to experimental data for studying inhibition and sensory encoding.Scientific reports · 2025Article
- Spatial constraints and cell surface molecule depletion structure a randomly connected learning circuit.Current biology : CB · 2025Article
- Review
- Local synaptic inhibition mediates cerebellar granule cell pattern separation and enables learned sensorimotor associations.Nature neuroscience · 2024Article
- An emergent temporal basis set robustly supports cerebellar time-series learning.Journal of neurophysiology · 2023Article
- Structure of Long-Range Direct and Indirect Spinocerebellar Pathways as Well as Local Spinal Circuits Mediating Proprioception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- A cerebellum inspired spiking neural network as a multi-model for pattern classification and robotic trajectory prediction.Frontiers in neuroscience · 2022Article
- Computational models of neurotransmission at cerebellar synapses unveil the impact on network computation.Frontiers in computational neuroscience · 2022Review
- The relationship between birth timing, circuit wiring, and physiological response properties of cerebellar granule cells.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Bidirectional learning in upbound and downbound microzones of the cerebellum.Nature reviews. Neuroscience · 2021Review
- Acetylcholine Modulates Cerebellar Granule Cell Spiking by Regulating the Balance of Synaptic Excitation and Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Neocortex-Cerebellum Circuits for Cognitive Processing.Trends in neurosciences · 2020Review
- Corollary Discharge Signals in the Cerebellum.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Review
- Sensorimotor Coding of Vermal Granule Neurons in the Developing Mammalian Cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Article
- Review
- Pathway-Specific Drive of Cerebellar Golgi Cells Reveals Integrative Rules of Cortical Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Response Dynamics in an Olivocerebellar Spiking Neural Network With Non-linear Neuron Properties.Frontiers in computational neuroscience · 2019Article
- Recent advances in understanding the mechanisms of cerebellar granule cell development and function and their contribution to behavior.F1000Research · 2018Review
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2 authors.
Funding
Abstract
Combinatorial expansion by the cerebellar granule cell layer (GCL) is fundamental to theories of cerebellar contributions to motor control and learning. Granule cells (GrCs) sample approximately four mossy fiber inputs and are thought to form a combinatorial code useful for pattern separation and learning. We constructed a spatially realistic model of the cerebellar GCL and examined how GCL architecture contributes to GrC combinatorial diversity. We found that GrC combinatorial diversity saturates quickly as mossy fiber input diversity increases, and that this saturation is in part a consequence of short dendrites, which limit access to diverse inputs and favor dense sampling of local inputs. This local sampling also produced GrCs that were combinatorially redundant, even when input diversity was extremely high. In addition, we found that mossy fiber clustering, which is a common anatomical pattern, also led to increased redundancy of GrC input combinations. We related this redundancy to hypothesized roles of temporal expansion of GrC information encoding in service of learned timing, and we show that GCL architecture produces GrC populations that support both temporal and combinatorial expansion. Finally, we used novel anatomical measurements from mice of either sex to inform modeling of sparse and filopodia-bearing mossy fibers, finding that these circuit features uniquely contribute to enhancing GrC diversification and redundancy. Our results complement information theoretic studies of granule layer structure and provide insight into the contributions of granule layer anatomical features to afferent mixing.
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