Evidence map›Paper›PMID 29118061›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 Expression.

Timothy L Lochmann, Konstantinos V Floros, Mitra Naseri, Krista M Powell, Wade Cook, Ryan J March, Giovanna T Stein, Patricia Greninger, Yuki Kato Maves, Laura R Saunders and 9 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 1 synthesis or guideline pooled it, 129 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Targeting protein-protein interactions in the BCL-2 family: opportunities for precision oncology.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  4. BCL-2/BCL-xL inhibitor pelcitoclax with osimertinib forJournal for immunotherapy of cancer · 2026
    Article
  5. Hallmarks of the ageing lung: 10 years later.The European respiratory journal · 2026
    Review
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  11. Article
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 1 country.

Timothy L LochmannVCU Philips Institute, School of Dentistry and Massey Cancer Center; Richmond, Virginia.
Konstantinos V FlorosVCU Philips Institute, School of Dentistry and Massey Cancer Center; Richmond, Virginia.
Mitra NaseriVCU Philips Institute, School of Dentistry and Massey Cancer Center; Richmond, Virginia.
Krista M PowellVCU Philips Institute, School of Dentistry and Massey Cancer Center; Richmond, Virginia.
Wade CookVCU Philips Institute, School of Dentistry and Massey Cancer Center; Richmond, Virginia.
Ryan J MarchCenter for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.
Giovanna T SteinCenter for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.
Patricia GreningerCenter for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.
Yuki Kato MavesCrown Bioscience Inc, San Diego, California.
Laura R SaundersAbbVie Stemcentrx LLC, South San Francisco, California.
Scott J DyllaAbbVie Stemcentrx LLC, South San Francisco, California.
Carlotta CostaCenter for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.
Sosipatros A BoikosDivision of Hematology, Oncology, & Palliative Care, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.
Joel D LeversonAbbVie, North Chicago, Illinois.
Andrew J SouersAbbVie, North Chicago, Illinois.
Geoffrey W KrystalDepartment of Internal Medicine, Virginia Commonwealth University, McGuire Veterans Affairs Medical Center, Richmond, Virginia.
Hisashi HaradaVCU Philips Institute, School of Dentistry and Massey Cancer Center; Richmond, Virginia. acfaber@vcu.edu cbenes@mgh.harvard.edu hharada@vcu.edu.
Cyril H BenesCenter for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts. acfaber@vcu.edu cbenes@mgh.harvard.edu hharada@vcu.edu.
Anthony C FaberVCU Philips Institute, School of Dentistry and Massey Cancer Center; Richmond, Virginia. acfaber@vcu.edu cbenes@mgh.harvard.edu hharada@vcu.edu.
Virginia Cancer Institute · USCenter for Cancer Research · USAbbVie (United States) · USChemoCentryx (United States) · USAngiocrine Bioscience (United States) · USHunter Holmes McGuire VA Medical Center · USVirginia Commonwealth University · US

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Keri R Maher · 1985 to 2026
$51.0M
Assessing BIM expression as a cause and marker for resistance to targeted therapiK22CA175276 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI FABER, ANTHONY CHARLES · 2014 to 2016
$573k
NCI NIH HHS K22 CA175276NCI NIH HHS P30 CA016059Wellcome Trust 102696
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene ExpressionAnimalsAntineoplastic AgentsApoptosisBridged Bicyclo Compounds, HeterocyclicCell Line, TumorDisease Models, AnimalDNA MethylationDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHumansLung NeoplasmsMicePromoter Regions, GeneticProto-Oncogene Proteins c-bcl-2Small Cell Lung CarcinomaAntineoplastic AgentsBridged Bicyclo Compounds, HeterocyclicProto-Oncogene Proteins c-bcl-2Sulfonamidesvenetoclax

Identifiers

PMID29118061
PMCPMC5771805
OpenAlexW2767246174

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.