Evidence map›Paper›PMID 29118054›Full record

ArticleBMJ open2017

Vitamin D status in chronic fatigue syndrome/myalgic encephalomyelitis: a cohort study from the North-West of England.

Kate E Earl, Giorgos K Sakellariou, Melanie Sinclair, Manuel Fenech, Fiona Croden, Daniel J Owens, Jonathan Tang, Alastair Miller, Clare Lawton, Louise Dye and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Kate E EarlDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, Liverpool, UK.
Giorgos K SakellariouDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, Liverpool, UK.
Melanie SinclairDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, Liverpool, UK.
Manuel FenechDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, Liverpool, UK.
Fiona CrodenHuman Appetite Research Unit, School of Psychology, University of Leeds, Leeds, UK.
Daniel J OwensResearch Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, UK.
Jonathan TangDepartment of Medicine, Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich Research Park, Norwich, UK.
Alastair MillerTropical and Infectious Disease Unit, Royal Liverpool University Hospital, Liverpool, UK.
Clare LawtonHuman Appetite Research Unit, School of Psychology, University of Leeds, Leeds, UK.
Louise DyeHuman Appetite Research Unit, School of Psychology, University of Leeds, Leeds, UK.
Graeme L CloseResearch Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, UK.
William D FraserDepartment of Medicine, Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich Research Park, Norwich, UK.
Anne McArdleDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, Liverpool, UK.
Michael B J BeadsworthDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, Liverpool, UK.
University of Liverpool · GBUniversity of Leeds · GBLiverpool John Moores University · GBNorwich Research Park · GBRoyal Liverpool University Hospital · GBUniversity of East Anglia · GB

Funding

Medical Research Council G0701603Medical Research Council MR/J002895/1
6 · The paper itself

Abstract

objectiveSevere vitamin D deficiency is a recognised cause of skeletal muscle fatigue and myopathy. The aim of this study was to examine whether chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is associated with altered circulating vitamin D metabolites.

designCohort study.

settingUK university hospital, recruiting from April 2014 to April 2015.

participantsNinety-two patients with CFS/ME and 94 age-matched healthy controls (HCs).

main outcome measuresThe presence of a significant association between CFS/ME, fatigue and vitamin D measures.

resultsNo evidence of a deficiency in serum total 25(OH) vitamin D (25(OH)D

conclusionsLow serum concentrations of total 25(OH)D do not appear to be a contributing factor to the level of fatigue of CFS/ME.

Indexed as

EncephalomyelitisFatigueFatigue Syndrome, ChronicVitamin D DeficiencyCase-Control StudiesEnglandHumansVitamin DVitamin DCFS/MEchronic fatigue syndromemyalgic encephalomyelitissupplementsVitamin D

Identifiers

PMID29118054
PMCPMC5695299
OpenAlexW2767377046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.