Evidence map›Paper›PMID 29118028›Full record

ArticleAmerican journal of physiology. Cell physiology2018

Dynamic functional contribution of the water channel AQP5 to the water permeability of peripheral lens fiber cells.

Rosica S Petrova, Kevin F Webb, Ehsan Vaghefi, Kerry Walker, Kevin L Schey, Paul J Donaldson

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. AQP5 Regulates Corneal Nerve Distribution Through NETRIN-1 and SLIT3.Investigative ophthalmology & visual science · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Physiological Cooperation between Aquaporin 5 and TRPV4.International journal of molecular sciences · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. The Role of Aquaporins in Ocular Lens Homeostasis.International journal of molecular sciences · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Rosica S PetrovaDepartment of Physiology, School of Medical Sciences, University of Auckland , Auckland , New Zealand.
Kevin F WebbDepartment of Physiology, School of Medical Sciences, University of Auckland , Auckland , New Zealand.
Ehsan VaghefiSchool of Optometry and Vision Sciences, New Zealand National Eye Centre, University of Auckland , Auckland , New Zealand.
Kerry WalkerDepartment of Physiology, School of Medical Sciences, University of Auckland , Auckland , New Zealand.
Kevin L ScheyDepartment of Biochemistry, Vanderbilt University , Nashville, Tennessee.
Paul J DonaldsonDepartment of Physiology, School of Medical Sciences, University of Auckland , Auckland , New Zealand.
University of Auckland · NZVanderbilt University · US

Funding

THE ROLE OF LENS MIP IN AGING AND CATARACTOGENESISR01EY013462 · NEI · VANDERBILT UNIVERSITY · PI Kevin L Schey · 2001 to 2026
$8.2M
NEI NIH HHS R01 EY013462
6 · The paper itself

Abstract

Although the functionality of the lens water channels aquaporin 1 (AQP1; epithelium) and AQP0 (fiber cells) is well established, less is known about the role of AQP5 in the lens. Since in other tissues AQP5 functions as a regulated water channel with a water permeability (P

Indexed as

AnimalsAquaporin 5AquaporinsCell MembraneEpithelial CellsEye ProteinsLens, CrystallineMercuric ChlorideMice, Inbred C57BLModels, BiologicalOrgan Culture TechniquesPermeabilityRats, WistarSpecies SpecificityTime FactorsWaterAqp5 protein, mouseAqp5 protein, rataquaporin 0Aquaporin 5AquaporinsEye ProteinsMercuric ChlorideWateraquaporin (AQP)fiber cell membrane vesicleshydrostatic pressure of the lenslenswater permeability

Identifiers

PMID29118028
PMCPMC5866439
OpenAlexW2767942308

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.