Evidence map›Paper›PMID 29118019›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2018

Acyloxyacyl hydrolase modulates pelvic pain severity.

Wenbin Yang, Ryan E Yaggie, Mingchen C Jiang, Charles N Rudick, Joseph Done, Charles J Heckman, John M Rosen, Anthony J Schaeffer, David J Klumpp

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. [Urodynamic and histological evaluation of cyclophosphamide-induced bladder pain syndrome in SD rats].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022
    Article
  6. Article
  7. Review
  8. Acyloxyacyl hydrolase is a host determinant of gut microbiome-mediated pelvic pain.American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Article
  9. Article
  10. Acyloxyacyl hydrolase regulates voiding activity.American journal of physiology. Renal physiology · 2020
    Article
  11. Article
  12. Acyloxyacyl hydrolase modulates depressive-like behaviors through aryl hydrocarbon receptor.American journal of physiology. Regulatory, integrative and comparative physiology · 2019
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Wenbin YangDepartment of Urology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois.
Ryan E YaggieDepartment of Urology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois.
Mingchen C JiangDepartment of Physiology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois.
Charles N RudickDepartment of Urology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois.
Joseph DoneDepartment of Urology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois.
Charles J HeckmanDepartment of Physiology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois.
John M RosenDepartment of Pediatric Gastroenterology, Children's Mercy, Kansas City, Missouri.
Anthony J SchaefferDepartment of Urology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois.
David J KlumppDepartment of Urology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois.
Northwestern University · USChildren's Mercy Hospital · US

Funding

Role of CNS in Modulation of Pelvic Pain SyndromeU01DK082342 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KLUMPP, DAVID J · 2008 to 2021
$10.5M
University of Michigan MAPP Research Network Discovery SiteU01DK082345 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLAUW, DANIEL J, CLEMENS, J. QUENTIN · 2008 to 2021
$9.7M
ROLE OF TNF IN BLADDER INFLAMMATIONR01DK066112 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KLUMPP, DAVID J · 2003 to 2010
$1.8M
NIDDK NIH HHS R01 DK066112NIDDK NIH HHS U01 DK082342NIDDK NIH HHS U01 DK082345
6 · The paper itself

Abstract

Chronic pelvic pain causes significant patient morbidity and is a challenge to clinicians. Using a murine neurogenic cystitis model that recapitulates key aspects of interstitial cystitis/bladder pain syndrome (IC), we recently showed that pseudorabies virus (PRV) induces severe pelvic allodynia in BALB/c mice relative to C57BL/6 mice. Here, we report that a quantitative trait locus (QTL) analysis of PRV-induced allodynia in F2

Indexed as

AnimalsBehavior, AnimalCarboxylic Ester HydrolasesCystitis, InterstitialDisease Models, AnimalEscherichia coli InfectionsFemaleGenetic Predisposition to DiseaseHyperalgesiaMaleMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutPain PerceptionPain ThresholdPelvic Painacyloxyacyl hydrolaseCarboxylic Ester HydrolasesTumor Necrosis Factor-alphaVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseallodyniaAOAHpelvic painpseudorabies virusQTL

Identifiers

PMID29118019
PMCPMC5899250
OpenAlexW2767961427

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.