Evidence map›Paper›PMID 29118011›Full record

ArticleGenome research2017

Comparative genome analysis of programmed DNA elimination in nematodes.

Jianbin Wang, Shenghan Gao, Yulia Mostovoy, Yuanyuan Kang, Maxim Zagoskin, Yongqiao Sun, Bing Zhang, Laura K White, Alice Easton, Thomas B Nutman and 4 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Genome research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 124 citations in OpenAlex.

  1. Article
  2. Review
  3. Programmed DNA elimination was present in the last common ancestor ofbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The enigma of the B chromosome-specific behaviour.Frontiers in plant science · 2026
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
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  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Jianbin WangDepartment of Biochemistry and Molecular Genetics, RNA Bioscience Initiative, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.ORCID 0000-0003-3155-894X
Shenghan GaoDepartment of Biochemistry and Molecular Genetics, RNA Bioscience Initiative, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.
Yulia MostovoyCardiovascular Research Institute, UCSF School of Medicine, San Francisco, California 94158, USA.
Yuanyuan KangDepartment of Biochemistry and Molecular Genetics, RNA Bioscience Initiative, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.
Maxim ZagoskinDepartment of Biochemistry and Molecular Genetics, RNA Bioscience Initiative, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.
Yongqiao SunBeijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
Bing ZhangBeijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
Laura K WhiteDepartment of Biochemistry and Molecular Genetics, RNA Bioscience Initiative, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.
Alice EastonLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, USA.
Thomas B NutmanLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, USA.
Pui-Yan KwokCardiovascular Research Institute, UCSF School of Medicine, San Francisco, California 94158, USA.
Songnian HuBeijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
Martin K NielsenGluck Equine Research Center, University of Kentucky, Lexington, Kentucky 40546, USA.
Richard E DavisDepartment of Biochemistry and Molecular Genetics, RNA Bioscience Initiative, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.ORCID 0000-0003-2242-3234
University of Colorado Denver · USChinese Academy of Sciences · CNNational Institutes of Health · USUniversity of California, San Francisco · USUniversity of Kentucky · US

Funding

Molecular Definition Of Filarial And Related Nonfilarial Genes And ProteinsZIAAI000512 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NUTMAN, THOMAS · 2009 to 2025
$9.9M
IN VIVO ANALYSIS OF SL ADDITION IN ASCARIS EMBRYOSR01AI049558 · NIAID · UNIVERSITY OF COLORADO DENVER · PI DAVIS, RICHARD E. · 2000 to 2015
$4.8M
Chromatin diminution in nematodesR01AI114054 · NIAID · UNIVERSITY OF COLORADO DENVER · PI DAVIS, RICHARD E. · 2015 to 2019
$2.5M
Genome analysis of Ascaris programmed DNA eliminationR21AI125869 · NIAID · UNIVERSITY OF COLORADO DENVER · PI WANG, JIANBIN · 2017 to 2018
$428k
NIAID NIH HHS R01 AI049558NIAID NIH HHS R01 AI114054NIAID NIH HHS R21 AI125869
6 · The paper itself

Abstract

Programmed DNA elimination is a developmentally regulated process leading to the reproducible loss of specific genomic sequences. DNA elimination occurs in unicellular ciliates and a variety of metazoans, including invertebrates and vertebrates. In metazoa, DNA elimination typically occurs in somatic cells during early development, leaving the germline genome intact. Reference genomes for metazoa that undergo DNA elimination are not available. Here, we generated germline and somatic reference genome sequences of the DNA eliminating pig parasitic nematode

Indexed as

DNA, HelminthAlternative SplicingAnimalsAscaridoideaAscaris suumChromosome BreakageChromosome BreakpointsEvolution, MolecularFemaleGenomeGerm-Line MutationMaleMolecular Sequence AnnotationNematodaRepetitive Sequences, Nucleic AcidRNA, HelminthDNA, HelminthRNA, Helminth

Identifiers

PMID29118011
PMCPMC5741062
OpenAlexW2767466964

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.