Evidence map›Paper›PMID 29117866›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2017

Ambulatory systolic blood pressure and obesity are independently associated with left ventricular hypertrophic remodeling in children.

Linyuan Jing, Christopher D Nevius, Cassi M Friday, Jonathan D Suever, Arichanah Pulenthiran, Abba Mejia-Spiegeler, H Lester Kirchner, William J Cochran, Gregory J Wehner, Aftab S Chishti and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Hypertension in middle childhood.BMC pediatrics · 2026
    Article
  3. [Combined measurement of serum macrophage M1/M2 markers and prediction of early cardiac lesions in obese children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Cardio-metabolic risk factors during childhood in relation to lung function and asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Linyuan JingDepartment of Imaging Science and Innovation, Geisinger, 100 North Academy Avenue, Danville, PA, 17822-4400, USA.
Christopher D NeviusDepartment of Imaging Science and Innovation, Geisinger, 100 North Academy Avenue, Danville, PA, 17822-4400, USA.
Cassi M FridayDepartment of Imaging Science and Innovation, Geisinger, 100 North Academy Avenue, Danville, PA, 17822-4400, USA.
Jonathan D SueverDepartment of Imaging Science and Innovation, Geisinger, 100 North Academy Avenue, Danville, PA, 17822-4400, USA.
Arichanah PulenthiranDepartment of Imaging Science and Innovation, Geisinger, 100 North Academy Avenue, Danville, PA, 17822-4400, USA.
Abba Mejia-SpiegelerDepartment of Imaging Science and Innovation, Geisinger, 100 North Academy Avenue, Danville, PA, 17822-4400, USA.
H Lester KirchnerBiomedical and Translational Informatics Institute, Geisinger, Danville, PA, USA.
William J CochranPediatric Gastroenterology, Geisinger, Danville, PA, USA.
Gregory J WehnerDepartment of Biomedical Engineering, University of Kentucky, Lexington, KY, USA.
Aftab S ChishtiDivision of Nephrology, Hypertension and Renal Transplantation, University of Kentucky, Lexington, KY, USA.
Christopher M HaggertyDepartment of Imaging Science and Innovation, Geisinger, 100 North Academy Avenue, Danville, PA, 17822-4400, USA.
Brandon K FornwaltDepartment of Imaging Science and Innovation, Geisinger, 100 North Academy Avenue, Danville, PA, 17822-4400, USA. bkf@gatech.edu.
Geisinger Medical Center · USGeisinger Neuroscience Institute · USUniversity of Kentucky · US

Funding

The role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2012 to 2017
$13.7M
NIGMS NIH HHS P20 GM103527
6 · The paper itself

Abstract

backgroundChildren with obesity have hypertrophic cardiac remodeling. Hypertension is common in pediatric obesity, and may independently contribute to hypertrophy. We hypothesized that both the degree of obesity and ambulatory blood pressure (ABP) would independently associate with measures of hypertrophic cardiac remodeling in children.

methodsChildren, aged 8-17 years, prospectively underwent cardiovascular magnetic resonance (CMR) and ABP monitoring. Left ventricular (LV) mass indexed to height

resultsSeventy-two children were recruited, and 68 of those (37 healthy weight and 31 obese/overweight) completed both CMR and ABP monitoring. Obese/overweight children had increased LVMI (27 ± 4 vs 22 ± 3 g/m

conclusionsIn children, both the degree of obesity and ambulatory blood pressures are independently associated with measures of cardiac hypertrophic remodeling, however the correlations were generally stronger for the degree of obesity. This suggests that interventions targeted at weight loss or obesity-associated co-morbidities including hypertension may be effective in reversing or preventing cardiac remodeling in obese children.

Indexed as

Blood PressureVentricular Function, LeftVentricular RemodelingAdolescentAge FactorsBlood Pressure Monitoring, AmbulatoryBody Mass IndexChildChi-Square DistributionCross-Sectional StudiesFemaleHumansHypertensionHypertrophy, Left VentricularLinear ModelsMagnetic Resonance Imaging, CineAmbulatory blood pressure monitoringCardiovascular magnetic resonanceHypertensionPediatric obesityVentricular remodeling

Identifiers

PMID29117866
PMCPMC5679494
OpenAlexW2767339341

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.