Evidence map›Paper›PMID 29117563›Full record

ArticleCell reports2017

Outcomes of Congenital Zika Disease Depend on Timing of Infection and Maternal-Fetal Interferon Action.

Jinling Chen, Yuejin Liang, Panpan Yi, Lanman Xu, Hal K Hawkins, Shannan L Rossi, Lynn Soong, Jiyang Cai, Ramkumar Menon, Jiaren Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 98 citations in OpenAlex.

  1. Article
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  11. Zika virus infection histories in brain development.Disease models & mechanisms · 2023
    Review
  12. Article
  13. Article
  14. Article
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Jinling ChenDepartment of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu 226001, China, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Yuejin LiangDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Panpan YiDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Infectious Diseases, Key Laboratory of Viral Hepatitis of Hunan, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Lanman XuDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Infectious Diseases, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China.
Hal K HawkinsDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Shannan L RossiDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA.
Lynn SoongDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA.
Jiyang CaiDepartment of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA.
Ramkumar MenonDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Jiaren SunDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: jisun@utmb.edu.
The University of Texas Medical Branch at Galveston · USFirst Affiliated Hospital of Wenzhou Medical University · CNNantong University · CNXiangya Hospital Central South University · CN

Funding

Retinoic Acid Regulates S100 Proteins and Immune Responses in Viral HepatitisR21AI126371 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SUN, JIAREN · 2016 to 2017
$426k
NIAID NIH HHS R21 AI126371
6 · The paper itself

Abstract

Zika virus (ZIKV) infection during pregnancy in humans results in intrauterine growth restriction, spontaneous abortion, and microcephaly. Here, we found that fetus-derived type I interferon (IFN-I) signaling can enhance anti-ZIKV responses and provide clinical benefits to the fetus. Because IFN-λ shares signaling cascades and antiviral functions with IFN-I, we investigated the in vivo effects of IFN-λ in ZIKV-infected pregnant mice. IFN-λ administration during mid-pregnancy reduced ZIKV burden in maternal and fetal organs and alleviated placental injuries and fetal demise. In addition, prophylactic and therapeutic treatment of IFN-λ1 in a human trophoblast line, as well as in primary human amniotic epithelial cells, greatly reduced the ZIKV burden. Our data highlight IFN-λ1 as a potential therapeutic useful for women at risk for congenital Zika disease.

Indexed as

AnimalsAntiviral AgentsCells, CulturedChlorocebus aethiopsFemaleFetal Growth RetardationFetusHumansInterferon-alphaInterferon LambdaInterferonsInterleukinsMiceMice, Inbred C57BLMice, KnockoutMyxovirus Resistance ProteinsAntiviral AgentsInterferon-alphaInterferon Lambdainterferon-lambda, humanInterferonsInterleukinsMx1 protein, mouseMyxovirus Resistance Proteinsanimal modelantiviralcongenital infectiongestational stagehuman pregnancyinterferon-λZika virus

Identifiers

PMID29117563
PMCPMC5726784
OpenAlexW2767916436

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.