Evidence map›Paper›PMID 29117559›Full record

ArticleCell reports2017

An Eye Organoid Approach Identifies Six3 Suppression of R-spondin 2 as a Critical Step in Mouse Neuroretina Differentiation.

Nozomu Takata, Deepti Abbey, Luciano Fiore, Sandra Acosta, Ruopeng Feng, Hyea Jin Gil, Alfonso Lavado, Xin Geng, Ashley Interiano, Geoffrey Neale and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

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  16. Retinal Ganglion Cell Replacement: Current Status and Challenges Ahead.Developmental dynamics : an official publication of the American Association of Anatomists · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Nozomu TakataCenter for Vascular and Developmental Biology, Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL 60611, USA.
Deepti AbbeyDepartment of Genetics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Luciano FioreCenter for Vascular and Developmental Biology, Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL 60611, USA.
Sandra AcostaCenter for Vascular and Developmental Biology, Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL 60611, USA.
Ruopeng FengDepartment of Genetics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Hyea Jin GilCenter for Vascular and Developmental Biology, Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL 60611, USA.
Alfonso LavadoDepartment of Genetics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Xin GengDepartment of Genetics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Ashley InterianoDepartment of Genetics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Geoffrey NealeHartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Mototsugu EirakuLaboratory for in vitro Histogenesis, RIKEN Center for Developmental Biology, Kobe, Hyogo 650-0047, Japan; Laboratory of Developmental Systems, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Kyoto 606-8507, Japan.
Yoshiki SasaiLaboratory for Organogenesis and Neurogenesis, RIKEN Center for Developmental Biology, Kobe, Hyogo 650-0047, Japan.
Guillermo OliverCenter for Vascular and Developmental Biology, Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL 60611, USA. Electronic address: guillermo.oliver@northwestern.edu.
St. Jude Children's Research Hospital · USNorthwestern University · USGenesis Research Institute · JPKyoto University · JP

Funding

Homeobox Gene Six3 in Forebrain and Visual System DevelopmentR01EY012162 · NEI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI OLIVER, GUILLERMO C · 1998 to 2015
$5.3M
NEI NIH HHS R01 EY012162
6 · The paper itself

Abstract

Recent advances in self-organizing, 3-dimensional tissue cultures of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) provided an in vitro model that recapitulates many aspects of the in vivo developmental steps. Using Rax-GFP-expressing ESCs, newly generated Six3

Indexed as

AnimalsAxin ProteinCell Culture TechniquesCell DifferentiationCells, CulturedEmbryo, MammalianEmbryonic Stem CellsEye ProteinsHomeobox Protein SIX3Homeodomain ProteinsInduced Pluripotent Stem CellsIn Situ Hybridization, FluorescenceIntercellular Signaling Peptides and ProteinsMiceMice, TransgenicNerve Tissue ProteinsAxin2 protein, mouseAxin ProteinEye ProteinsHomeobox Protein SIX3Homeodomain ProteinsIntercellular Signaling Peptides and ProteinsNerve Tissue ProteinsRax protein, mouseRSPO2 protein, mouseR-SpondinsSox2 protein, mouseSOXB1 Transcription FactorsThrombospondinsTranscription FactorsVsx2 protein, mouseWnt8a protein, mouseWnt Proteinseyemouseneuroretinaoptic vesiclesorganoidspluripotent stem cellsR-spondinsSix3Six3 conditional knockout ESCsWnt

Identifiers

PMID29117559
PMCPMC5728169
OpenAlexW2767656091

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.