ArticleBiophysical journal2017
Structure, Mechanics, and Instability of Fibrin Clot Infected with Staphylococcus epidermidis.
Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Biomechanical control of vascular morphogenesis by the surrounding stiffness.Nature communications · 2025Article
- Article
- Bacterial interactions with platelets: defining key themes.Frontiers in immunology · 2025Review
- Speckle fluctuations reveal dynamics of microparticles in fibrin scaffolds in a model of bacterial infection.npj biological physics and mechanics · 2025Article
- Histopathological composition of thrombus material in a large cohort of patients with acute ischemic stroke: a study of atypical clots.Frontiers in neurology · 2025Article
- Fibrin protofibril packing and clot stability are enhanced by extended knob-hole interactions and catch-slip bonds.Blood advances · 2022Article
- Recent advances in metal-organic framework-based materials for anti-staphylococcus aureus infection.Nano research · 2022Review
- Passive and Active Microrheology for Biomedical Systems.Frontiers in bioengineering and biotechnology · 2022Review
- Review
- Strength and deformability of fibrin clots: Biomechanics, thermodynamics, and mechanisms of rupture.Acta biomaterialia · 2021Article
- Article
- Article
- Damped White Noise Diffusion with Memory for Diffusing Microprobes in Ageing Fibrin Gels.Biophysical journal · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Health care-associated infection, over half of which can be attributed to indwelling medical devices, is a strong risk factor for thromboembolism. Although most experimental models of medical device infection draw upon isolated bacterial biofilms, in fact there is no infection without host protein contribution. Here we study, to our knowledge, a new model for medical device infection-that of an infected fibrin clot-and show that the common blood-borne pathogen Staphylococcus epidermidis influences this in vitro model of a blood clot mechanically and structurally on both microscopic and macroscopic scales. Bacteria present during clot formation produce a visibly disorganized microstructure that increases clot stiffness and triggers mechanical instability over time. Our results provide insight into the observed correlation between medical device infection and thromboembolism; the increase in model clot heterogeneity shows that S. epidermidis can rupture a fibrin clot. The resultant embolization of the infected clot can contribute to the systemic dissemination of the pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.