SynthesisJournal of the National Cancer Institute2017
Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry.
Registry-linked trialOpen access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Journal of the National Cancer Institute, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01221168 (ProGene), which is not on this map. Cited by 54 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 3 pooled it
6.5field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ProGene: Etude Genetique et Epidemiologique du Cancer de la Prostate Familial
Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects.Nature communications · 2023Pooled it
- Evidence of Novel Susceptibility Variants for Prostate Cancer and a Multiancestry Polygenic Risk Score Associated with Aggressive Disease in Men of African Ancestry.European urology · 2023Pooled it
- Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.Nature communications · 2018Pooled it
- The Multiethnic Cohort: A Resource for the Study of Genetic and Nongenetic Cancer Risk across Populations.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Incorporating external risk information with the Cox model under population heterogeneity: applications to trans-ancestry polygenic hazard scores.Journal of the Royal Statistical Society. Series A, (Statistics in Society) · 2026Article
- Non-coding genetic variants underlying higher prostate cancer risk in men of African ancestry.Nature communications · 2025Article
- Does inclusion of neighborhood variables improve clinical risk prediction for advanced prostate cancer in Black and White men?Urologic oncology · 2025Article
- Genomic landscape of cancer in racially and ethnically diverse populations.Nature reviews. Genetics · 2025Review
- Racial disparity in prostate cancer: an outlook in genetic and molecular landscape.Cancer metastasis reviews · 2024Review
- Genetic Risk Loci and Familial Associations in Migraine: A Genome-Wide Association Study in the Han Chinese Population of Taiwan.Journal of clinical neurology (Seoul, Korea) · 2024Article
- Prostate Cancer Among Black Men in Canada.JAMA network open · 2024Observational
- Genetic and biological drivers of prostate cancer disparities in Black men.Nature reviews. Urology · 2024Review
- Prostate cancer genetic risk and associated aggressive disease in men of African ancestry.Nature communications · 2023Article
- Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.Nature genetics · 2023Article
- Association of rare, recurrent nonsynonymous variants in the germline of prostate cancer patients of African ancestry.The Prostate · 2023Article
- Article
- PRState: Incorporating genetic ancestry in prostate cancer risk scores for men of African ancestry.BMC cancer · 2022Article
- Prostate cancer screening in Black men in Canada: a case for risk-stratified care.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2022Article
- Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa.Genome biology · 2022Article
- Racial disparities in prostate cancer among black men: epidemiology and outcomes.Prostate cancer and prostatic diseases · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
89 authors at 20 institutions in 8 countries.
David V ContiDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Kan WangDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Xin ShengDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Jeannette T BensenDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Dennis J HazelettBioinformatics and Computational Biology Research Center, Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA.
Michael B CookDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Sue A InglesDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Rick A KittlesUniversity of Arizona College of Medicine and University of Arizona Cancer Center, Tucson, AZ.
Sara S StromDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX.
Benjamin A RybickiDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI.
Barbara NemesureDepartment of Preventive Medicine, Stony Brook University, Stony Brook, NY.
William B IsaacsJames Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, MD.
Janet L StanfordDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN.
Maureen SandersonDepartment of Family and Community Medicine, Meharry Medical College, Nashville, TN.
Esther M JohnCalifornia Prevention Institute of California, Fremont, CA.
Jong Y ParkDepartment of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL.
Jianfeng XuProgram for Personalized Cancer Care and Department of Surgery, NorthShore University HealthSystem, Evanston, IL.
Victoria L StevensEpidemiology Research Program, American Cancer Society, Atlanta, GA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Chad D HuffDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX.
Zhaoming WangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.
Edward D YeboahUniversity of Ghana Medical School, Accra, Ghana.
Yao TetteyUniversity of Ghana Medical School, Accra, Ghana.
Richard B BiritwumUniversity of Ghana Medical School, Accra, Ghana.
Andrew A AdjeiUniversity of Ghana Medical School, Accra, Ghana.
Evelyn TayUniversity of Ghana Medical School, Accra, Ghana.
Ann TrueloveWestat, Rockville, MD.
Shelley NiwaWestat, Rockville, MD.
Thomas A SellersDepartment of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL.
Kosj YamoahDepartment of Radiation Oncology and Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL.
Adam B MurphyDepartment of Urology, Northwestern University, Chicago, IL.
Dana C CrawfordInstitute for Computational Biology, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH.
Susan M GapsturEpidemiology Research Program, American Cancer Society, Atlanta, GA.
William S BushInstitute for Computational Biology, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH.
Melinda C AldrichDivision of Epidemiology, Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN.
Olivier CussenotCeRePP, GRC No. 5 ONCOTYPE-URO, Institut Universitaire de Cancérologie, UPMC Univ Paris 6, Paris, France.
Gyorgy PetrovicsDepartment of Surgery, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, MD.
Jennifer CullenDepartment of Surgery, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, MD.
Christine Neslund-DudasDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI.
Mariana C SternDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Zsofia-Kote JaraiThe Institute of Cancer Research, Sutton, London, UK.
Koveela GovindasamiOncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK.
Anand P ChokkalingamSchool of Public Health, University of California, Berkeley, Berkeley, CA.
Ann W HsingDepartment of Medicine, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA.
Phyllis J GoodmanSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA.
Thomas HoffmannDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA.
Bettina F DrakeDepartment of Surgery, Division of Public Health Sciences, Washington University School of Medicine, St. Louis, MO.
Jennifer J HuSylvester Comprehensive Cancer Center and Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL.
Peter E ClarkVanderbilt University Medical Center, Nashville, TN.
Stephen K Van Den EedenDivision of Research, Kaiser Permanente Northern California, Oakland, CA.
Pascal BlanchetUniversity Hospital of Pointe-à-Pitre, Guadeloupe.
Jay H FowkeDepartment of Medicine and Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN.
Graham CaseyCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA.
Anselm J M HennisDepartment of Preventive Medicine, Stony Brook University, Stony Brook, NY.
Ying HanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Alexander LubwamaSchool of Public Health, Makerere University College of Health Sciences, Kampala, Uganda.
Ian M ThompsonDepartment of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX.
Robin LeachDepartment of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Fredrick SchumacherDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH.
David J Van den BergDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Susan M GundellDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Alex StramDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Peggy WanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Lucy XiaDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Loreall C PoolerDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
James L MohlerLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Elizabeth T H FonthamSchool of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA.
Gary J SmithDepartment of Urology, Roswell Park Cancer Institute, Buffalo, NY.
Jack A TaylorEpigenetic and Stem Cell Biology Laboratory and Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC.
Shiv SrivastavaDepartment of Surgery, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, MD.
Rosalind A EelesThe Institute of Cancer Research, Sutton, London, UK.
John CarptenDepartment of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Adam S KibelDivision of Urology, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Boston, MA.
Luc MultignerInserm U1085 - IRSET, Rennes, France.
Marie-Elise ParentINRS-Institut Armand-Frappier, Institut National de la Recherche Scientifique, University of Quebec, Laval, Quebec, Canada (MEP).
Florence MenegauxInserm, Team Cancer-Environment, Center for Research in Epidemiology and Population Health, Université Paris-Saclay, Université Paris-Sud, Villejuif, France.
Geraldine Cancel-TassinCeRePP, GRC No. 5 ONCOTYPE-URO, Institut Universitaire de Cancérologie, UPMC Univ Paris 6, Paris, France.
Eric A KleinGlickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH.
Laurent BrureauUniversity Hospital of Pointe-à-Pitre, Guadeloupe.
Daniel O StramDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Stephen WatyaSchool of Public Health, Makerere University College of Health Sciences, Kampala, Uganda.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.
John S WitteDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA.
William J BlotDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN.
Brian E HendersonDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
PRACTICAL/ELLIPSE Consortium
University of Southern California · USCase Western Reserve University · USKorle Bu Teaching Hospital · GHMoffitt Cancer Center · USUniformed Services University of the Health Sciences · USVanderbilt University Medical Center · USAmerican Cancer Society · USFred Hutch Cancer Center · USHenry Ford Hospital · USInstitut de Recherche en Santé, Environnement et Travail · FRNational Institutes of Health · USRoswell Park Comprehensive Cancer Center · USRoyal Marsden NHS Foundation Trust · GBSorbonne Université · FRStony Brook University · USThe University of Texas Health Science Center at San Antonio · USThe University of Texas MD Anderson Cancer Center · USUniversity of California, San Francisco · USUniversity of Ghana · GHVanderbilt University · US
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5MThe RCMI Program in Health Disparities Research at Meharry Medical College - SupplementU54MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI Maureen Sanderson · 2017 to 2026
$48.2MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3MSAN ANTONIO CENTER OF BIOMARKERS OF RISK FOR PROSTATE CAU01CA086402 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LEACH, ROBIN JEAN, THOMPSON, IAN M. · 2000 to 2018
$33.1MPLCO Trial Etiologic and Early Marker StudyZIACP010152 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MOORE, STEVEN · 2009 to 2025
$29.9MTranslational Pathology CoreU54CA163069 · NCI · MEHARRY MEDICAL COLLEGE · PI BALLARD, BILLY RAY · 2011 to 2025
$18.8MMeharry RCMI Program in Women's Health ResearchG12MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI HILDRETH, JAMES E · 2012 to 2016
$7.8MGenetic Epidemiology of Prostate Cancer Risk and ProgressionR01CA088164 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAN DEN EEDEN, STEPHEN K., WITTE, JOHN S. · 2000 to 2015
$6.1MPCPT and SELECT cohorts: Core Infrastructure Support for Cancer Research UM1CA182883 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TANGEN, CATHERINE M., THOMPSON, IAN M. · 2013 to 2017
$5.2MUnraveling Genetic Determinants of Lung Cancer Risk in African AmericansK07CA172294 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALDRICH, MELINDA · 2013 to 2017
$801kCancer Research UK 15007Cancer Research UK 17528NCI NIH HHS K07 CA172294NCI NIH HHS P30 CA016086NCI NIH HHS R01 CA088164NCI NIH HHS U01 CA086402NCI NIH HHS U54 CA163069NCI NIH HHS UM1 CA182883NIEHS NIH HHS P30 ES010126NIMHD NIH HHS G12 MD007586
Abstract
Prostate cancer incidence is 1.6-fold higher in African Americans than in other populations. The risk factors that drive this disparity are unknown and potentially consist of social, environmental, and genetic influences. To investigate the genetic basis of prostate cancer in men of African ancestry, we performed a genome-wide association meta-analysis using two-sided statistical tests in 10 202 case subjects and 10 810 control subjects. We identified novel signals on chromosomes 13q34 and 22q12, with the risk-associated alleles found only in men of African ancestry (13q34: rs75823044, risk allele frequency = 2.2%, odds ratio [OR] = 1.55, 95% confidence interval [CI] = 1.37 to 1.76, P = 6.10 × 10-12; 22q12.1: rs78554043, risk allele frequency = 1.5%, OR = 1.62, 95% CI = 1.39 to 1.89, P = 7.50 × 10-10). At 13q34, the signal is located 5' of the gene IRS2 and 3' of a long noncoding RNA, while at 22q12 the candidate functional allele is a missense variant in the CHEK2 gene. These findings provide further support for the role of ancestry-specific germline variation in contributing to population differences in prostate cancer risk.
Indexed as
Genetic LociGenetic Predisposition to DiseasePolymorphism, Single NucleotideBlack or African AmericanBlack PeopleCase-Control StudiesCheckpoint Kinase 2Chromosomes, Human, Pair 13Chromosomes, Human, Pair 22Gene FrequencyGenome-Wide Association StudyHumansInsulin Receptor Substrate ProteinsMaleProstatic NeoplasmsCheckpoint Kinase 2CHEK2 protein, humanInsulin Receptor Substrate ProteinsIRS2 protein, human
Identifiers
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Read underepoch 390
Registered trials
NCT01221168ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.