ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017
Group B Streptococcal Disease Worldwide for Pregnant Women, Stillbirths, and Children: Why, What, and How to Undertake Estimates?
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06833957 (PReparing for OptimalPhase III/IV maTErnal Group B StreptococCal Vaccine Trials in Africa), which is not on this map. Cited by 71 papers, 14 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PReparing for OptimalPhase III/IV maTErnal Group B StreptococCal Vaccine Trials in Africa (PROTECT)
Who cites it
71 citing papers in PubMed, 14 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- Maternal colonization with group B Streptococcus and antibiotic resistance in China: systematic review and meta-analyses.Annals of clinical microbiology and antimicrobials · 2023Pooled it
- Invasive group A streptococcal disease in pregnant women and young children: a systematic review and meta-analysis.The Lancet. Infectious diseases · 2022Pooled it
- Group B streptococcus infection during pregnancy and infancy: estimates of regional and global burden.The Lancet. Global health · 2022Pooled it
- Burden of invasive group B Streptococcus disease in non-pregnant adults: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Pooled it
- Maternal Disease With Group B Streptococcus and Serotype Distribution Worldwide: Systematic Review and Meta-analyses.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Pooled it
- Maternal Colonization With Group B Streptococcus and Serotype Distribution Worldwide: Systematic Review and Meta-analyses.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Pooled it
- Risk of Early-Onset Neonatal Group B Streptococcal Disease With Maternal Colonization Worldwide: Systematic Review and Meta-analyses.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Pooled it
- Intrapartum Antibiotic Chemoprophylaxis Policies for the Prevention of Group B Streptococcal Disease Worldwide: Systematic Review.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Pooled it
- Stillbirth With Group B Streptococcus Disease Worldwide: Systematic Review and Meta-analyses.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Pooled it
- Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Pooled it
- Neonatal Encephalopathy With Group B Streptococcal Disease Worldwide: Systematic Review, Investigator Group Datasets, and Meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Pooled it
- Neurodevelopmental Impairment in Children After Group B Streptococcal Disease Worldwide: Systematic Review and Meta-analyses.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Pooled it
- Preterm Birth Associated With Group B Streptococcus Maternal Colonization Worldwide: Systematic Review and Meta-analyses.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Pooled it
- Rectal and Vaginal Eradication ofNutrients · 2019Trial
- Prevalence, Serotype Distribution, and Antimicrobial Resistance ofJournal of clinical medicine · 2026Article
- Group B Streptococcus antibiotics treatment during pregnancy and the risk of four neurodevelopmental outcomes in Swedish children.Scientific reports · 2026Article
- The bacterial cell membrane acts as a dynamic heme reservoir during group BbioRxiv : the preprint server for biology · 2026Article
- Determinants of susceptibility and tolerance ofInfection and immunity · 2026Review
- Maternal Group BClinical epidemiology · 2026Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 18 institutions in 8 countries.
Funding
Abstract
Improving maternal, newborn, and child health is central to Sustainable Development Goal targets for 2030, requiring acceleration especially to prevent 5.6 million deaths around the time of birth. Infections contribute to this burden, but etiological data are limited. Group B Streptococcus (GBS) is an important perinatal pathogen, although previously focus has been primarily on liveborn children, especially early-onset disease. In this first of an 11-article supplement, we discuss the following: (1) Why estimate the worldwide burden of GBS disease? (2) What outcomes of GBS in pregnancy should be included? (3) What data and epidemiological parameters are required? (4) What methods and models can be used to transparently estimate this burden of GBS? (5) What are the challenges with available data? and (6) How can estimates address data gaps to better inform GBS interventions including maternal immunization? We review all available GBS data worldwide, including maternal GBS colonization, risk of neonatal disease (with/without intrapartum antibiotic prophylaxis), maternal GBS disease, neonatal/infant GBS disease, and subsequent impairment, plus GBS-associated stillbirth, preterm birth, and neonatal encephalopathy. We summarize our methods for searches, meta-analyses, and modeling including a compartmental model. Our approach is consistent with the World Health Organization (WHO) Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER), published in The Lancet and the Public Library of Science (PLoS). We aim to address priority epidemiological gaps highlighted by WHO to inform potential maternal vaccination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.