ArticlePloS one2017
General response of Salmonella enterica serovar Typhimurium to desiccation: A new role for the virulence factors sopD and sseD in survival.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recent progress in molecular mechanisms of Salmonella effectors involved in gut epithelium invasion.Molecular biology reports · 2025Pooled it
- Article
- How Salmonella Works Under Osmotic and Desiccation Stresses.Comprehensive reviews in food science and food safety · 2026Review
- Genomic and epidemiologic evidence for attenuated virulence inFrontiers in microbiology · 2026Article
- Genomic survey of multidrug resistant Salmonella enterica serovar Minnesota clones in chicken products.npj antimicrobials and resistance · 2025Article
- Antimicrobial Efficacy of GS-2 on Reusable Food Packaging Materials for Specialty Crops.Foods (Basel, Switzerland) · 2024Article
- Gene Networks Analysis ofIranian journal of biotechnology · 2023Article
- Enhancing cell resistance for production of mixed microbiological reference materials with Salmonella and coliforms by freeze-drying.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Salmonella enterica Outbreaks Linked to the Consumption of Tahini and Tahini-Based ProductsMicroorganisms · 2022Review
- Thermal Death Kinetics of Three RepresentativeMicroorganisms · 2022Article
- Pre-Growth Environmental Stresses Affect Foodborne Pathogens Response to Subsequent Chemical Treatments.Microorganisms · 2022Article
- Detection ofTheScientificWorldJournal · 2022Article
- Salmonella Genomics in Public Health and Food Safety.EcoSal Plus · 2021Article
- Genetic Determinants of Stress Resistance in Desiccated Salmonella enterica.Applied and environmental microbiology · 2021Article
- Type 3 secretion system 1 of Salmonella typhimurium and its inhibitors: a novel strategy to combat salmonellosis.Environmental science and pollution research international · 2021Review
- Analysis of In Vivo Transcriptome of Intracellular Bacterial PathogenPathogens (Basel, Switzerland) · 2021Article
- Impact of the Resistance Responses to Stress Conditions Encountered in Food and Food Processing Environments on the Virulence and Growth Fitness of Non-TyphoidalFoods (Basel, Switzerland) · 2021Review
- Transcriptional response of Bacillus megaterium FDU301 to PEG200-mediated arid stress.BMC microbiology · 2020Article
- Type three secretion system in Salmonella Typhimurium: the key to infection.Genes & genomics · 2020Review
- Identification of Novel Genes Mediating Survival ofFrontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salmonella can survive for long periods under extreme desiccation conditions. This stress tolerance poses a risk for food safety, but relatively little is known about the molecular and cellular regulation of this adaptation mechanism. To determine the genetic components involved in Salmonella's cellular response to desiccation, we performed a global transcriptomic analysis comparing S. enterica serovar Typhimurium cells equilibrated to low water activity (aw 0.11) and cells equilibrated to high water activity (aw 1.0). The analysis revealed that 719 genes were differentially regulated between the two conditions, of which 290 genes were up-regulated at aw 0.11. Most of these genes were involved in metabolic pathways, transporter regulation, DNA replication/repair, transcription and translation, and, more importantly, virulence genes. Among these, we decided to focus on the role of sopD and sseD. Deletion mutants were created and their ability to survive desiccation and exposure to aw 0.11 was compared to the wild-type strain and to an E. coli O157:H7 strain. The sopD and sseD mutants exhibited significant cell viability reductions of 2.5 and 1.3 Log (CFU/g), respectively, compared to the wild-type after desiccation for 4 days on glass beads. Additional viability differences of the mutants were observed after exposure to aw 0.11 for 7 days. E. coli O157:H7 lost viability similarly to the mutants. Scanning electron microscopy showed that both mutants displayed a different morphology compared to the wild-type and differences in production of the extracellular matrix under the same conditions. These findings suggested that sopD and sseD are required for Salmonella's survival during desiccation.
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