ArticlePloS one2017
Dietary amino acid and vitamin complex protects honey bee from immunosuppression caused by Nosema ceranae.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 106 citations in OpenAlex.
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- Chemical Composition and Antioxidant Activity of Prokupac Grape Pomace Extract: Implications for Redox Modulation in Honey Bee Cells.Antioxidants (Basel, Switzerland) · 2025Article
- Simultaneous Determination of 10 Fat-Soluble Vitamins by Ultra-Performance Liquid Chromatography in Multivitamins With Minerals Capsules.Journal of separation science · 2025Article
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- Bee-Inspired Healing: Apitherapy in Veterinary Medicine for Maintenance and Improvement Animal Health and Well-Being.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Enhancing Honey Bee Health: Evaluating Pollen Substitute Diets in Field and Cage Experiments.Insects · 2024Article
- Potential of Wormwood and Oak Bark-Based Supplement in Health Improvement ofAnimals : an open access journal from MDPI · 2024Article
- Monitoring the Season-Prevalence Relationship ofInsects · 2024Article
- Comparative Study of the Effect of Pollen Substitute Diets on Honey Bees during Early Spring.Insects · 2024Article
- Beneficial Bacteria and Plant Extracts Promote Honey Bee Health and Reduce Nosema ceranae Infection.Probiotics and antimicrobial proteins · 2024Article
- Effects of natural treatments on the varroa mite infestation levels and overall health of honey bee (Apis mellifera) colonies.PloS one · 2024Article
- Production, characterization and therapeutic efficacy of egg yolk antibodies specific to Nosema ceranae.PloS one · 2024Article
- Effects of Plant-Based Supplement on Oxidative Stress of Honey Bees (Animals : an open access journal from MDPI · 2023Article
- A Comprehensive Review on the Roles of Metals Mediating Insect-Microbial Pathogen Interactions.Metabolites · 2023Review
- Ternary Mixture of Azoxystrobin, Boscalid and Pyraclostrobin Disrupts the Gut Microbiota and Metabolic Balance of Honeybees (International journal of molecular sciences · 2023Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microsporidium Nosema ceranae is well known for exerting a negative impact on honey bee health, including down-regulation of immunoregulatory genes. Protein nutrition has been proven to have beneficial effects on bee immunity and other aspects of bee health. Bearing this in mind, the aim of our study was to evaluate the potential of a dietary amino acid and vitamin complex "BEEWELL AminoPlus" to protect honey bees from immunosuppression induced by N. ceranae. In a laboratory experiment bees were infected with N. ceranae and treated with supplement on first, third, sixth and ninth day after emergence. The expression of genes for immune-related peptides (abaecin, apidaecin, hymenoptaecin, defensin and vitellogenin) was compared between groups. The results revealed significantly lower (p<0.01 or p<0.001) numbers of Nosema spores in supplemented groups than in the control especially on day 12 post infection. With the exception of abacein, the expression levels of immune-related peptides were significantly suppressed (p<0.01 or p<0.001) in control group on the 12th day post infection, compared to bees that received the supplement. It was supposed that N. ceranae had a negative impact on bee immunity and that the tested amino acid and vitamin complex modified the expression of immune-related genes in honey bees compromised by infection, suggesting immune-stimulation that reflects in the increase in resistance to diseases and reduced bee mortality. The supplement exerted best efficacy when applied simultaneously with Nosema infection, which can help us to assume the most suitable period for its application in the hive.
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