ArticlePLoS neglected tropical diseases2017
Quantitative label-free proteomic analysis of human urine to identify novel candidate protein biomarkers for schistosomiasis.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- An update on non-invasive urine diagnostics for human-infecting parasitic helminths: what more could be done and how?Parasitology · 2020Pooled it
- Utility of recombinant Schistosoma bovis 22.6 kDa antigen for diagnosis of human urogenital schistosomiasis by ELISA: a cross-sectional study in Yewa North LGA, Ogun State, Nigeria.BMC infectious diseases · 2026Article
- Preliminary screening of urinary host protein biomarkers for Schistosomiasis haematobium: A proteome profiling study identifying candidate diagnostic targets in school-aged children.PLoS neglected tropical diseases · 2025Article
- Exploring urinary proteomics and peptidomics biomarkers for the diagnosis of mekong schistosomiasis.Heliyon · 2024Article
- RNA-seq gene expression profiling of the bladder in a mouse model of urogenital schistosomiasis.bioRxiv : the preprint server for biology · 2024Article
- Human schistosomiasis in Nigeria: present status, diagnosis, chemotherapy, and herbal medicines.Parasitology research · 2023Review
- Scoping review: bladder cancer in Nigeria - what are the gaps in clinical care and research?BMJ open · 2022Article
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- HBFP: a new repository for human body fluid proteome.Database : the journal of biological databases and curation · 2021Article
- Parasite-derived microRNAs as a diagnostic biomarker: potential roles, characteristics, and limitations.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Review
- Human body-fluid proteome: quantitative profiling and computational prediction.Briefings in bioinformatics · 2021Review
- Proteomics Investigations of Potential Protein Biomarkers in Sera of Rabbits Infected WithFrontiers in cellular and infection microbiology · 2021Article
- Heat shock protein 70 (Hsp70) inParasitology · 2020Review
- Preliminary study of the urinary proteome in Li and Han ethnic individuals from Hainan.Science China. Life sciences · 2020Article
- Biomarker discovery and beyond for diagnosis of bladder diseases.Bladder (San Francisco, Calif.) · 2020Article
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- MS1 ion current-based quantitative proteomics: A promising solution for reliable analysis of large biological cohorts.Mass spectrometry reviews · 2019Review
- Understanding Urogenital Schistosomiasis-Related Bladder Cancer: An Update.Frontiers in medicine · 2018Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSchistosomiasis is a chronic neglected tropical disease that is characterized by continued inflammatory challenges to the exposed population and it has been established as a possible risk factor in the aetiology of bladder cancer. Improved diagnosis of schistosomiasis and its associated pathology is possible through mass spectrometry to identify biomarkers among the infected population, which will influence early detection of the disease and its subtle morbidity. METHODOLOGY: A high-throughput proteomic approach was used to analyse human urine samples for 49 volunteers from Eggua, a schistosomiasis endemic community in South-West, Nigeria. The individuals were previously screened for Schistosoma haematobium and structural bladder pathologies via microscopy and ultrasonography respectively. Samples were categorised into schistosomiasis, schistosomiasis with bladder pathology, bladder pathology, and a normal healthy control group. These samples were analysed to identify potential protein biomarkers.
resultsA total of 1306 proteins and 9701 unique peptides were observed in this study (FDR = 0.01). Fifty-four human proteins were found to be potential biomarkers for schistosomiasis and bladder pathologies due to schistosomiasis by label-free quantitative comparison between groups. Thirty-six (36) parasite-derived potential biomarkers were also identified, which include some existing putative schistosomiasis biomarkers that have been previously reported. Some of these proteins include Elongation factor 1 alpha, phosphopyruvate hydratase, histone H4 and heat shock proteins (HSP 60, HSP 70).
conclusionThese findings provide an in-depth analysis of potential schistosoma and human host protein biomarkers for diagnosis of chronic schistosomiasis caused by Schistosoma haematobium and its pathogenesis.
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