ArticlePloS one2017
Persistence of hepatitis E virus in the liver of non-viremic naturally infected wild boar.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Hepatitis E Virus in the Iberian Peninsula: A Systematic Review.Food and environmental virology · 2023Pooled it
- Hepatitis E virus surveillance in wild ruminants from northwestern Italy: results of a three-year molecular survey.Veterinary research communications · 2026Article
- Article
- Hepatitis E Virus Exposure Across Multiple Host Species in a Shared Ecosystem in Argentina.Veterinary sciences · 2026Article
- Hepatitis E and Potential Public Health Implications from a One-Health Perspective: Special Focus on the European Wild Boar (Pathogens (Basel, Switzerland) · 2024Review
- Prevalence ofOne health (Amsterdam, Netherlands) · 2024Article
- Evidence of Circulation and Phylogenetic Analysis of Hepatitis E Virus (HEV) in Wild Boar in South-East Italy.Viruses · 2023Article
- Hepatitis E Virus in the Wild Boar Population: What Is the Real Zoonotic Risk in Portugal?Tropical medicine and infectious disease · 2023Article
- 15 years overview of European zoonotic surveys in wild boar and red deer: A systematic review.One health (Amsterdam, Netherlands) · 2023Review
- Monitoring of hepatitis E virus in zoo animals from Spain, 2007-2021.Transboundary and emerging diseases · 2022Article
- Presence of hepatitis E virus in testis of naturally infected wild boars.Transboundary and emerging diseases · 2022Article
- Hepatitis E virus in the endangered Iberian lynx (Lynx pardinus).Transboundary and emerging diseases · 2022Article
- Hepatitis E Virus Detection in Hunted Wild Boar Liver and Muscle Tissues in Central Italy.Microorganisms · 2022Article
- Long-Term Determinants of the Seroprevalence of the Hepatitis E Virus in Wild Boar (Animals : an open access journal from MDPI · 2021Article
- Clinical significance of post-liver transplant hepatitis E seropositivity in high prevalence area of hepatitis E genotype 3: a prospective study.Scientific reports · 2020Article
- Article
- First Serological Evidence on Endemicity of HEV Infection in Wild Boar (Sus scrofa) Populations from Portugal.Virologica Sinica · 2018Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis E virus (HEV) is an emerging zoonotic pathogen with pigs and wild boar serving as reservoirs for human infection through direct contact with infected animals or the consumption of raw or undercooked pork products. The liver is considered the main target site of HEV replication in swine and an important organ in the pathogenesis of the disease. The aim of this study was to characterize the target liver cells for HEV entry in naturally infected wild boar and to evaluate the type and severity of the pathological changes in order to reach a better understanding of the hepatic pathogenic mechanisms involved in hepatitis E. In total, 58 livers from hunted wild boar were histopathologically evaluated. The presence of specific HEV antibodies in serum was determined by indirect ELISA. Immunohistochemistry was used for the detection of HEV antigen and Real time RT-PCR to detect HEV RNA in liver and serum. HEV seroprevalence in these animals was of 5.197% (CI95%: 1.77-14.14). By Real time RT-PCR, HEV was detected in the liver tissue of four wild boar (6.8%; CI95%: 2.7-16.4) and only one animal was also positive in serum (1.7%; CI95%: 0.3-9.1). The non-viremic animals naturally infected with HEV presented evidence of liver infection, mainly in Kupffer cells and liver sinusoidal endothelial cells, without apparent associated hepatitis lesions. This study supports the hypothesis that low viral titers may persist in the liver of non-viremic individuals, giving thus the possibility of consumption of contaminated liver of animals diagnosed as HEV-negative in serum. Further immunopathogenic studies are necessary to elucidate the mechanisms responsible for this process and to evaluate the protocols of HEV diagnosis in animals destined for human consumption.
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