ArticleACS applied materials & interfaces2017
Nanotopographic Regulation of Human Mesenchymal Stem Cell Osteogenesis.
Article in ACS applied materials & interfaces, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 69 citations in OpenAlex.
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- Anisotropic nanospikes on micro and nanoscale hierarchical titanium surfaces enhance early osseointegration of dental implants.Discover nano · 2026Article
- Research on the regulation of osteogenic differentiation and mechanotransduction by porous bionic coatings on titanium alloy implant surfaces.RSC advances · 2026Article
- The effects of nanopillar and nanopit arrays on the morphology and osteogenic differentiation of adipose-derived stem cells.Applied microscopy · 2026Article
- Silver-deposited titanium as a prophylactic 'nano coat' for peri-implantitis.Nanoscale advances · 2024Article
- Cobalt-doped layered hydroxide coating on titanium implants promotes vascularization and osteogenesis for accelerated fracture healing.Materials today. Bio · 2024Article
- Thermoresponsive Smart Copolymer Coatings Based on P(NIPAM-ACS biomaterials science & engineering · 2023Article
- Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells.World journal of stem cells · 2023Review
- Distinct and overlapping functions of YAP and TAZ in tooth development and periodontal homeostasis.Frontiers in cell and developmental biology · 2023Review
- Integrating physicomechanical and biological strategies for BTE: biomaterials-induced osteogenic differentiation of MSCs.Theranostics · 2023Review
- The influence of nanotopography on cell behaviour through interactions with the extracellular matrix - A review.Bioactive materials · 2022Review
- Soft overcomes the hard: Flexible materials adapt to cell adhesion to promote cell mechanotransduction.Bioactive materials · 2022Review
- Nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective.Future science OA · 2022Review
- Nanoscale Surface Topography Reduces Focal Adhesions and Cell Stiffness by Enhancing Integrin Endocytosis.Nano letters · 2021Article
- Graphene oxide-functionalized nanocomposites promote osteogenesis of human mesenchymal stem cells via enhancement of BMP-SMAD1/5 signaling pathway.Biomaterials · 2021Article
- Biocompatibility of nanomaterials and their immunological properties.Biomedical materials (Bristol, England) · 2021Review
- YAP and TAZ Mediators at the Crossroad between Metabolic and Cellular Reprogramming.Metabolites · 2021Review
- New perspectives on the roles of nanoscale surface topography in modulating intracellular signaling.Current opinion in solid state & materials science · 2021Article
- An overview of signaling pathways regulating YAP/TAZ activity.Cellular and molecular life sciences : CMLS · 2021Review
- Biophysical Stimuli as the Fourth Pillar of Bone Tissue Engineering.Frontiers in cell and developmental biology · 2021Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Mesenchymal stem cell (MSC) differentiation can be manipulated by nanotopographic interface providing a unique strategy to engineering stem cell therapy and circumventing complex cellular reprogramming. However, our understanding of the nanotopographic-mechanosensitive properties of MSCs and the underlying biophysical linkage of the nanotopography-engineered stem cell to directed commitment remains elusive. Here, we show that osteogenic differentiation of human MSCs (hMSCs) can be largely promoted using our nanoengineered topographic glass substrates in the absence of dexamethasone, a key exogenous factor for osteogenesis induction. We demonstrate that hMSCs sense and respond to surface nanotopography, through modulation of adhesion, cytoskeleton tension, and nuclear activation of TAZ (transcriptional coactivator with PDZ-binding motif), a transcriptional modulator of hMSCs. Our findings demonstrate the potential of nanotopographic surfaces as noninvasive tools to advance cell-based therapies for bone engineering and highlight the origin of biophysical response of hMSC to nanotopography.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.