ArticleHippocampus2018
Increased hippocampus to ventromedial prefrontal connectivity during the construction of episodic future events.
Article in Hippocampus, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed.
- Self-Processing Circuits Among Depressed Youth After Amygdala Neurofeedback Cued to the Self-Face.Journal of neuroscience research · 2025Article
- Mental time travel and insight in schizophrenia.Psychological medicine · 2025Review
- Scene construction deficits in adolescent PTSD are in sensory, rather than spatial, imagery.Frontiers in psychology · 2025Article
- Concurrent representations of reinstated and transformed memories and their modulation by reward.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Modeling the contribution of theta-gamma coupling to sequential memory, imagination, and dreaming.Frontiers in neural circuits · 2024Article
- Neurocognitive Model of Schema-Congruent and -Incongruent Learning in Clinical Disorders: Application to Social Anxiety and Beyond.Perspectives on psychological science : a journal of the Association for Psychological Science · 2023Article
- The double-edged sword of the hippocampus-ventromedial prefrontal cortex resting-state connectivity in stress susceptibility and resilience: A prospective study.Neurobiology of stress · 2023Article
- A model of working memory for encoding multiple items and ordered sequences exploiting the theta-gamma code.Cognitive neurodynamics · 2023Article
- Individual differences in the relationship between episodic detail generation and resting state functional connectivity vary with age.Neuropsychologia · 2022Article
- Loneliness is linked to specific subregional alterations in hippocampus-default network covariation.Journal of neurophysiology · 2021Article
- Hippocampal-Prefrontal Connectivity Prior to the COVID-19 Pandemic Predicts Stress Reactivity.Biological psychiatry global open science · 2021Article
- Hippocampal neurogenesis promotes preference for future rewards.Molecular psychiatry · 2021Article
- The relationship between hippocampal subfield volumes and autobiographical memory persistence.Hippocampus · 2021Article
- Article
- Differential reinforcement encoding along the hippocampal long axis helps resolve the explore-exploit dilemma.Nature communications · 2020Article
- Effective connectivity during autobiographical memory search.Brain and behavior · 2020Article
- Modulation of hippocampal brain networks produces changes in episodic simulation and divergent thinking.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The value of what's to come: Neural mechanisms coupling prediction error and the utility of anticipation.Science advances · 2020Article
- The role of the pre-commissural fornix in episodic autobiographical memory and simulation.Neuropsychologia · 2020Article
- Development of Hippocampal-Prefrontal Cortex Interactions through Adolescence.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Both the hippocampus and ventromedial prefrontal cortex (vmPFC) appear to be critical for episodic future simulation. Damage to either structure affects one's ability to remember the past and imagine the future, and both structures are commonly activated as part of a wider core network during future simulation. However, the precise role played by each of these structures and, indeed, the direction of information flow between them during episodic simulation, is still not well understood. In this study, we scanned participants using functional magnetic resonance imaging while they imagined future events in response to object cues. We then used dynamic causal modeling to examine effective connectivity between the left anterior hippocampus and vmPFC during the initial mental construction of the events. Our results show that while there is strong bidirectional intrinsic connectivity between these regions (i.e., irrespective of task conditions), only the hippocampus to vmPFC connection increases during the construction of episodic future events, suggesting that the hippocampus initiates event simulation in response to retrieval cues, driving activation in the vmPFC where episodic details may be further integrated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.